PMID: 8969723Dec 1, 1996Paper

Pneumococcal colonization in children with sickle cell disease [see comment

The Journal of Pediatrics
C F NorrisK L McGowan

Abstract

The goals of this prospective study were to define the Streptococcus pneumoniae colonization rate in children with sickle cell disease (SCD) at the Children's Hospital of Philadelphia and to determine the serotype and antibiotic susceptibility of all isolates. Children with SCD followed at the hospital were sampled for colonization with S. pneumoniae by means of a throat or nasopharyngeal swab on one or two occasions. Patient information was obtained when the specimen was collected. Specimens were isolated on gentamicin-blood agar plates and modified Avery broth. Antibiotic susceptibility was determined by a commercially available test (E-test). Isolates were serotyped with the use of type-specific antisera. The relationship between the data noted above and certain clinical parameters was examined. A total of 490 specimens were obtained from 278 patients. Twenty-eight patients had a culture positive for S. pneumoniae, resulting in an overall colonization rate of 10%. Thirty-three percent (11/33) of all isolates were resistant to penicillin-seven intermediately resistant and four highly resistant. Twelve percent of isolates were also resistant to cefotaxime. Eight different serotypes were identified; all but one are included in ...Continue Reading

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Citations

Jun 1, 1997·AIDS Patient Care and STDs·R M Rutstein, S E Starr
Mar 5, 2004·The Lancet Infectious Diseases·D BogaertP W M Hermans
May 1, 1997·Current Problems in Pediatrics·S L Kaplan
Nov 12, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·James McCaffreyNicholas J A Webb
Aug 10, 1999·The Pediatric Infectious Disease Journal·F GhaffarG H McCracken
Dec 23, 1999·The Pediatric Infectious Disease Journal·M B Harper

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