Pneumococcal disease burden, clinical presentations and vaccine coverage in the Jamaican population

Human Antibodies
R WillisM Smikle

Abstract

Pneumococcal serotypes circulating in any population vary over time and between countries and impacts the effectiveness of pneumococcal vaccination. This study investigated the epidemiology of pneumococcal disease in Jamaica. Streptococcus pneumoniae isolates (n= 349) along with demographic and clinical information were collected from patients presenting at the 4 major hospitals in Jamaica over a 2-year period. Serotyping was done using latex agglutination tests and the Quellung reaction assay. Invasive pneumococcal disease (IPD) incidence was 45.4/100,000 in children under 5 yrs and 16.3/100,000 in adults over 65 yrs. Thirteen serogroups were identified among the 120 isolates subjected to grouping; the most common being serogroups: 19 (22/120,18.3%), 6 (20/120,16.7%), 14 (20/120,16.7%), 23 (18/120,15.0%), 3 (11/120,9.2%) and nontypeable (8/120,2.3%). The estimated vaccine coverage rates for the PCV7 and PCV13 vaccines in children less than 5 yrs were 82.5% and 88.7% respectively. The 23-valent PPV23 provided 100% coverage rate in adults over 65 yrs and 82.9% coverage rate for the entire population. Pneumococcal vaccine coverage rates in Jamaica are comparable to those reported in certain developed countries and higher than in ...Continue Reading

References

May 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W Y WongD R Powars
Aug 18, 1999·The American Journal of Medicine·J C ButlerG M Carlone
Apr 30, 2003·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Upton D AllenDonald E Low
Oct 3, 2003·The New England Journal of Medicine·Keith P KlugmanUNKNOWN Vaccine Trialists Group
Dec 10, 2003·Journal of Clinical Microbiology·B M CharalambousS H Gillespie
Mar 10, 2004·Annals of Tropical Paediatrics·D McGregorC D Christie
Feb 22, 2005·Journal of Microbiological Methods·H-C Slotved, M B Kerrn
Jan 3, 2006·Seminars in Respiratory and Critical Care Medicine·Ake OrtqvistMats Kalin
Jul 31, 2008·Expert Review of Vaccines·Rolando Ulloa-Gutierrez, María L Avila-Aguero
Mar 20, 2009·Seminars in Respiratory and Critical Care Medicine·Joseph P Lynch, George G Zhanel
Aug 25, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Daniel J IsaacmanRalf R Reinert
Dec 14, 2016·Seminars in Respiratory and Critical Care Medicine·Hernán A Iannella, Carlos M Luna
Jul 14, 2017·Pneumonia·Serena TricaricoStuart C Clarke

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.