Pneumococcal infection in patients with systemic lupus erythematosus

Joint, Bone, Spine : Revue Du Rhumatisme
Juliet SchurderKarim Sacre

Abstract

Our study aimed to analyze the risk factors associated with the occurrence and severity of pneumococcal infection (PI) in systemic lupus erythematosus (SLE) patients. Medical records of all SLE patients admitted in our department from January 2005 to December 2014 were retrospectively reviewed. SLE patients were separated in 2 groups according to whether they had PI or not. Medical records of all consecutive patients (with and without SLE) admitted in our department for PI over the same period of time were also reviewed. Clinical characteristics associated with PI occurrence and severity were analyzed in SLE patients. One hundred and ninety SLE patients (42.2+14.9 years; 87.4% females) were hospitalized over a 10-year period. PI was the reason for admission in 6 (3.2%) patients, including 5 cases of invasive infection. With a follow-up of 2112.8 patient-years for the total cohort, incidence of invasive PI in SLE was of 236/100,000 patient-years. PI occurred at a younger age (43.5+14.9 versus 65.3+18.7 years, P<0.01) and were more severe, with a higher frequency of invasive infection (P<0.001) and higher need for ICU admission (P<0.05) in SLE as compared to non SLE patients. Risk factors associated with PI in SLE patients were a...Continue Reading

Citations

Jun 12, 2018·Current Opinion in Rheumatology·Alexis MathianZahir Amoura
Dec 12, 2019·Frontiers in Immunology·Chiara CantarelliPaolo Cravedi
Jan 26, 2021·Journal of Translational Autoimmunity·Michael Battaglia, Lee Ann Garrett-Sinha
Nov 13, 2021·Scandinavian Journal of Immunology·Lotte JensenAnja Poulsen
Aug 18, 2020·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Shilpa AroraMeenakshi Jolly
Dec 28, 2019·Pediatrics·Vidya SivaramanMonica I Ardura

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