PMID: 6869015Apr 1, 1983

Pneumococcal meningitis and bacteraemia in Danish children 1969-1978. Serotypes, incidence and outcome

Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology
F K Pedersen, J Henrichsen

Abstract

The incidence of pneumococcal meningitis in Danish children during 1969-1978 was estimated to be 2.1/year/100,000 children from 0 to 14 years old. Fifty-five per cent of 146 children with pneumococcal meningitis and 61% of 61 with bacteraemia were below 2 years of age. Mortality from meningitis was 13% and from bacteraemia 7%. Of the children with meningitis, 14% had sequelae at the time of discharge from the hospital. Sequelae were not seen after bacteraemia. Among 277 pneumococcal isolates from spinal fluid and blood from Danish children during 1969-1978, serotypes 14, 18C, 6A + 6B, 23F, 7F and 19F, in that order of frequency, were the most common ones, accounting for 69% of all isolates. Serotypes included in current 14-valent pneumococcal polysaccharide vaccines made of 80% of all types, when types 6A and 6B are considered together (because it has been shown that they offer cross-protection).

References

Sep 1, 1977·The Journal of Infectious Diseases·M Finland, M W Barnes
Jan 1, 1978·Proceedings of the Society for Experimental Biology and Medicine·J M BorgoñoM R Hilleman
Aug 1, 1978·The Journal of Pediatrics·J D SiegelR H Michaels
Dec 11, 1976·Lancet·G T WilliamsS Tabaqchali
Dec 18, 1976·Lancet·D R BairdB M Greenwood
Jan 1, 1974·Scandinavian Journal of Infectious Diseases·J Henrichsen
Mar 1, 1973·The Journal of Infectious Diseases·D W FraserR A Feldman
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Sep 13, 1980·Lancet·P H MäkeläP Karma
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Mar 14, 1964·British Medical Journal·J B HEYCOCK, T C NOBLE
Jan 1, 1964·Acta Pathologica Et Microbiologica Scandinavica·E LUND

Related Concepts

Meningitis, Pneumococcal, Penicillin-Resistant
Pneumococcal Infections
Serotyping
Streptococcus pneumoniae
Pyemia

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