Pneumococcal surface protein C contributes to sepsis caused by Streptococcus pneumoniae in mice

Infection and Immunity
Francesco IannelliGianni Pozzi

Abstract

The role of pneumococcal surface protein C (PspC; also called SpsA, CbpA, and Hic) in sepsis by Streptococcus pneumoniae was investigated in a murine infection model. The pspC gene was deleted in strains D39 (type 2) and A66 (type 3), and the mutants were tested by being injected intravenously into mice. The animals infected with the mutant strains showed a significant increase in survival, with the 50% lethal dose up to 250-fold higher than that for the wild type. Our findings indicate that PspC affords a decisive contribution to sepsis development.

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Related Concepts

SpsA protein, Streptococcus pneumoniae
Metazoa
Bacterial Proteins
DNA Sequence
DNA, Bacterial
Genes, Bacterial
Mice, Inbred CBA
Pneumococcal Infections
Streptococcus pneumoniae
Pathogenicity

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