PMID: 329Oct 1, 1975

Pneumococcal type-associated variability in alternate complement pathway activation

Infection and Immunity
D P Fine

Abstract

Opsonization of Streptococcus pneumoniae may be mediated by the alternate complement pathway. To study the importance of this interaction to human disease, complement consumption by pneumococci of various serotypes was measured in humwn serum chelated with ethyleneglycoltraacetic acid, a substance that blocks the classic but not the alternate complement pathwway. Serotype I, in contrast to all other types studied, lacked ability to consume complement in this system. The ability for serotypes III, IV, and VIII to activate the alternate pathway could be eliminated by prior serum absorption at O C with they type in question, a condition that would remove antibody but not complement. Types VII, XII, XIV, and XXV readily activated the alternate pathway in unabsorbed and absorbed sera. Differences could not be related to properties of the capsules. It was concluded that types I, III, IV, and VIII lack intrinsic ability to activate and thus be opsonized by the alternate complement pathway, although types III, IV, and VIII can do so in concert with specific antibody. The fact that these same types are especially prominent in human disease suggests that the ability to evade opsonization by the alternate complement pathway in pre-antibod...Continue Reading

Citations

Oct 1, 1983·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·C Rosén, J H Braconier
Jun 8, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Javier Garau, Esther Calbo
Jan 14, 2009·Infection and Immunity·Vishakha SabharwalStephen I Pelton
Dec 1, 1981·Annals of Tropical Paediatrics·F E Berkowitz
Apr 28, 2005·Scandinavian Journal of Immunology·M A BreukelsW Timens
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Jan 1, 1980·Transactions of the Royal Society of Tropical Medicine and Hygiene·B Rowan-KellyY H Thong
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Mar 20, 2013·Current Opinion in Pulmonary Medicine·Joaquín BurgosAlbert Pahissa

Related Concepts

Immune complex
Hemolytic Complement
Complement C3 precursor
Edetic Acid, Sodium Salt
Egtazic Acid Sodium Salt
Serotyping
Streptococcus pneumoniae
Zymosan

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