Pneumococcal urinary antigen test: diagnostic yield and impact on antibiotic treatment

The Clinical Respiratory Journal
Wendy LaijenW G Boersma

Abstract

The pneumococcal urinary antigen test (PUAT) is commonly used for the etiological diagnosis of community-acquired pneumonia (CAP) and can be useful for targeting pathogen-directed therapy. The aim of our study was to evaluate the diagnostic yield of the PUAT and the impact of a positive PUAT result on antibiotic treatment in patients with CAP in a clinical non-research setting. Adults hospitalized with CAP between January 2005 and November 2007 were studied retrospectively. All patients were tested by PUAT. The sensitivity of the PUAT was determined and changes in antibiotic therapy were assessed. A total of 681 patients with CAP were included. The microorganism most frequently identified was Streptococcus pneumoniae. It was found in 95 (14.0%) patients, and the PUAT increased the diagnostic yield to a total of 184 (27.0%) patients. The S. pneumoniae antigen was detected in 37 of 55 patients with definitive pneumococcal pneumonia (67.3%). Pneumococcal urinary antigen was positive in 56 of 95 pneumococcal cases (definite and probable), resulting in an overall test sensitivity of 59.0%. Positive results of the PUAT led physicians to narrow the spectrum of antibiotic treatment in 69 (45.1%) patients. The PUAT is a useful method fo...Continue Reading

References

Aug 10, 2002·The European Respiratory Journal. Supplement·M Woodhead
Jan 23, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Félix GutiérrezAlberto M Hidalgo
Mar 1, 2003·The European Respiratory Journal·M A MarcosA Torres
Jun 28, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David R MurdochJulie M Cook
Dec 31, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Beatriz RosónFrancesc Gudiol
Dec 23, 2004·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Tadashi IshidaMakiko Jinnai
Apr 4, 2007·Quality & Safety in Health Care·Jeroen A SchoutenRichard P T M Grol
Oct 3, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·F AndreoJ Domínguez
Dec 18, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Niclas JohanssonJonas Hedlund
Nov 1, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M F EngelJ J Oosterheert

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Citations

Jan 9, 2019·Expert Review of Anti-infective Therapy·Diego ViasusJordi Carratalà
Feb 1, 2019·Journal of Clinical Microbiology·Cinzia TavanoNicasio Mancini

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