Pneumococcal vaccination in adult solid organ transplant recipients: A review of current evidence

Vaccine
Claire DendleStephen Holdsworth

Abstract

This narrative review summarizes the current literature relating to pneumococcal vaccination in adult solid organ transplant (SOT) recipients, who are at risk of invasive pneumococcal disease (IPD) with its attendant high morbidity and mortality. The effect of the pneumococcal polysaccharide vaccine has been examined in several small cohort studies in SOT recipients, most of which were kidney transplant recipients. The outcomes for these studies have been laboratory seroresponses or functional antibody titers. Overall, in most of these studies the transplant recipients were capable of generating measurable serological responses to pneumococcal vaccination but these responses were less than those of healthy controls. A mathematical model estimated the effectiveness of polysaccharide vaccination in SOT recipients to be one third less than those of patients with HIV. The evidence for the efficacy of the pneumococcal conjugate vaccine in SOT is based on a small number of randomized controlled trials in liver and kidney transplant recipients. These trials demonstrated that SOT recipients mounted a serological response following vaccination however there was no benefit to the use of prime boosting (conjugate vaccine followed by polys...Continue Reading

Citations

Mar 7, 2020·Expert Review of Vaccines·L HolzerG T Rijkers
Aug 25, 2020·Lung India : Official Organ of Indian Chest Society·Raja DharParvaiz A Koul
Oct 20, 2020·Frontiers in Microbiology·Vanessa RaabeMark J Mulligan
Jun 3, 2021·Vaccines·Claire FronemanRicardo J José
Jul 9, 2021·Journal of Internal Medicine·Inge K HoldenIsik Somuncu Johansen

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