PMID: 8985536Dec 1, 1996Paper

Pneumocystis carinii and cytomegalovirus infections in severely ill, HIV-infected African infants

Annals of Tropical Paediatrics
P M JeenaV Chrystal

Abstract

Unlike in the industrialized world, in which Pneumocystis carinii and cytomegalovirus (CMV) are major respiratory opportunistic organisms, the causes of severe pneumonia, which accounts for much of the mortality in HIV-infected infants in developing countries, are not known, although tuberculosis has been associated with HIV in adults. We report on post-mortem lung and liver biopsies obtained soon after death from 36 HIV-infected infants and 36 HIV-uninfected matched controls who had been admitted with severe pneumonia to an ICU. Nineteen of the HIV-infected infants were classified by WHO criteria as having AIDS and 17 'symptomatic HIV'. P. carinii and CMV were detected significantly more frequently in lung tissue from the AIDS patients (14 of 18 samples tested, p < 0.01; 14 of 18 samples tested, p < 0.01, respectively) as compared with matched controls. P. carinii was detected in two of 13 lung biopsies from symptomatic HIV infants, but in none of the controls. Lung tissue obtained from AIDS patients had P. carinii and CMV more frequently (p < 0.01, p < 0.01, respectively) than that from symptomatic HIV patients. CMV was also detected in excess in liver tissue from AIDS infants (five of 18 samples) as compared with that from s...Continue Reading

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Citations

Mar 31, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·K J NathooP R Mason
Oct 3, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·N J HargreavesS B Squire
Apr 12, 2003·Current Opinion in Pulmonary Medicine·Stephen M Graham
Dec 22, 2010·The Pediatric Infectious Disease Journal·Stephen M GrahamMalcolm E Molyneux
Dec 15, 2010·The Pediatric Infectious Disease Journal·Marco ZampoliHeather J Zar
Jul 5, 2012·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Omolemo P KitchinRobin J Green
Feb 23, 2013·Current Opinion in Pulmonary Medicine·Matthew BatesAlimuddin Zumla
May 9, 2014·Viruses·Sonia M Restrepo-GualterosGustavo Nino
Jul 30, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Janneke A CoxRobert Colebunders
Oct 2, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·P BakakiC A Hart
Aug 5, 2000·The Pediatric Infectious Disease Journal·H J ZarG Hussey
Oct 18, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shabir A MadhiKeith P Klugman
Jan 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lynne M MofensonCathy Wilfert
Apr 22, 2010·Expert Review of Respiratory Medicine·Penny M EnarsonStephen M Graham
Aug 23, 2011·The Pediatric Infectious Disease Journal·Warunee PunpanichShabir A Madhi
Jan 22, 2019·Expert Opinion on Pharmacotherapy·James J C Nuttall
Jan 15, 2014·BMC Research Notes·Brenda M MorrowHeather J Zar
Dec 24, 2013·AIDS·Surbhi ModiUNKNOWN Child Survival Working Group of the Interagency Task Team on the Prevention and Treatment of HIV Infection in Pregnant Women
Nov 30, 2000·Current Infectious Disease Reports·P R Mason, D A Katzenstein
May 9, 2002·British Medical Bulletin·Stephen M Graham, Diana M Gibb
Jan 30, 2007·The Pediatric Infectious Disease Journal·Anniek J De BaetsIsidore E Pazvakavambwa
Dec 20, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David T FiskPowel H Kazanjian
Apr 30, 2009·Expert Review of Anti-infective Therapy·Diane Gray, Heather J Zar
Nov 24, 2021·Future Microbiology·Kerusha GovenderRaveen Parboosing

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