PMID: 9650017Jul 3, 1998Paper

Pneumocystis carinii induces interleukin 6 production by an alveolar epithelial cell line

European Journal of Clinical Investigation
S T PottratzJ L Sheldon

Abstract

Pneumocystis carinii (PC) infection often results in severe pneumonia in immunocompromised patients. Attachment of PC organisms to alveolar epithelial cells is a hallmark of PC pneumonia; however, few studies have investigated the response of alveolar epithelial cells to PC infection. Interleukin 6 (IL-6) is a multifunctional cytokine that is produced by alveolar epithelial cells in response to a variety of stimuli. Our investigation was undertaken to determine whether PC organisms induce production of IL-6 by alveolar epithelial cells and to determine the effect of IL-6 on PC attachment. Incubation of the human alveolar epithelial cell line, A549, with PC organisms resulted in a significant increase in IL-6 secreted into the cell culture media. Time-course studies showed that IL-6 production was detected as soon as 2 h after addition of PC and continued up to 48 h of exposure. Further studies demonstrated that preincubation of A549 cells with IL-6 resulted in a concentration-dependent increase in both A549 cell production of fibronectin and PC attachment. Thus, PC attachment to an alveolar epithelial cell line results in epithelial cell production of IL-6, which can act to further increase PC attachment. This may provide an im...Continue Reading

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Citations

Mar 10, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Geertrude H StruijkFrederike J Bemelman
Apr 23, 2005·Infection and Immunity·Jing WangTerry W Wright
Aug 18, 2001·American Journal of Respiratory Cell and Molecular Biology·R VassalloA H Limper
Dec 22, 2009·Future Microbiology·Michelle N Kelly, Judd E Shellito
Oct 18, 2018·Journal of Medical Microbiology·Theodore J KottomAndrew H Limper
Feb 17, 2005·Medical Mycology·Chad SteeleJay K Kolls
Feb 20, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jing WangTerry W Wright
May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer M SpethMarc Peters-Golden

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