PMID: 1732656Feb 12, 1992

Pneumocystis carinii pneumonia among patients without AIDS at a cancer hospital

JAMA : the Journal of the American Medical Association
Kent A SepkowitzD Armstrong

Abstract

To determine the predisposing factors, attack rate by underlying disease, and outcome of Pneumocystis carinii pneumonia among patients without the acquired immunodeficiency syndrome (AIDS) at a cancer center. Twelve-year retrospective review from a tertiary-care cancer center. One hundred forty patients, constituting 142 cases, with morphologically proved P carinii pneumonia. Hematologic malignancy (47%) (including lymphoma [27%] and leukemia [18%]), solid tumor (31%), or bone marrow transplantation (18%) was the underlying condition in the majority of cases. Twenty-five cases (18%) were diagnosed at autopsy. All but seven patients had previously established predisposing factors for P carinii pneumonia, including corticosteroid use in 87%. The attack rate for hospitalized patients with primary or metastatic brain tumor increased during the 12-year interval. The attack rates for hospitalized patients with hematologic neoplasm or bone marrow transplantation were stable. The overall mortality rate did not change during the period reviewed. Despite the availability of effective prophylaxis, P carinii pneumonia continues to occur among patients with neoplastic disease. In addition to patients with certain hematologic neoplasms, thos...Continue Reading

References

Dec 5, 2003·Lancet·Michail S Lionakis, Dimitrios P Kontoyiannis
Jan 21, 2014·Journal of Critical Care·Yousang KoKyeongman Jeon
Oct 10, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mini KambojKent A Sepkowitz
Apr 29, 2014·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Diamantis P KofteridisGeorge Samonis
Jun 1, 1995·The Journal of Clinical Investigation·D M O'RiordanAndrew H Limper
May 1, 1997·The Journal of Clinical Investigation·Andrew H LimperJ E Standing
Jul 16, 2003·The Journal of Infection·Angela C KimRobert S Holzman
Jul 1, 1993·American Journal of Respiratory Cell and Molecular Biology·M CastroAndrew H Limper
Apr 14, 1999·Australian and New Zealand Journal of Medicine·A K MillsJ G McCormack
Dec 10, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J P SouzaS W Crawford
Jan 24, 2014·Scandinavian Journal of Infectious Diseases·France RoblotGroupe d'Etudes et de Recherche en Infectiologie Clinique du Centre Ouest (GERICCO)
Mar 8, 2013·Hospital Practice·Aarti S Bhardwaj, Shyamala C Navada
Jun 15, 2011·Expert Review of Clinical Pharmacology·Jörg DietrichSantosh Kesari
Jul 7, 2007·Cancer Investigation·Abraham B SchwarzbergMatthew H Kulke
Oct 9, 1999·Critical Reviews in Diagnostic Imaging·C A Crans, P M Boiselle
Feb 24, 2001·The American Journal of the Medical Sciences·D A Russian, S J Levine
Oct 16, 2007·Chest·Guillaume BolléeElie Azoulay
Oct 3, 2012·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Kuan-Yeh LeeShan-Chwen Chang
Jan 23, 2016·Journal de mycologie médicale·Y DiengO Gaye
Aug 26, 2011·Médecine et maladies infectieuses·F FilyF Caron
Feb 23, 2010·Infectious Disease Clinics of North America·Emilie CatherinotOlivier Lortholary
Apr 21, 2009·Clinics in Chest Medicine·Bryan J KrajicekAndrew H Limper
Sep 2, 2008·Clinical Breast Cancer·Sara M TolaneyHarold J Burstein
Nov 23, 2006·Hematology/oncology Clinics of North America·Tracy T Batchelor, Thomas N Byrne
Apr 27, 2007·Pediatric Blood & Cancer·Pinki PrasadSadhna M Shankar
Sep 14, 2012·Arthritis Care & Research·M Kristen DemoruelleSterling West
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S I MartinAST Infectious Diseases Community of Practice
Nov 19, 2011·Transplant Infectious Disease : an Official Journal of the Transplantation Society·N Goto, S Oka
Jan 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S I MartinAST Infectious Diseases Community of Practice
Jul 1, 1993·Disease-a-month : DM·A S Rosenberg, A E Brown
Oct 1, 1993·Cancer Treatment Reviews·I Varthalitis, F Meunier
Aug 30, 2001·Critical Care Clinics·A Safdar, D Armstrong

Related Concepts

Hematologic Neoplasms
Pneumocystis Infections
Hospitals, Cancer
Therapeutic Immunosuppression
Neoplastic Syndromes, Hereditary
Pneumocystis Jiroveci Pneumonia
Brain Neoplasms
Opportunistic Infections
Brachydactyly
Cross Infection

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