Pneumocystis carinii pneumonia in patients with primary brain tumors

Archives of Neurology
J W HensonA O Fels


All histologically documented episodes of Pneumocystis carinii pneumonia in adult patients with primary brain tumors treated at Memorial Sloan-Kettering Cancer Center, New York, NY, since 1981, were retrospectively reviewed. Pneumocystis carinii pneumonia was histologically documented 11 times in 10 patients. During the same 8-year interval, approximately 587 adults were seen at the center for a brain tumor, 90% of whom received ongoing therapy. Therefore, in at least 1.7% (10/587) of our patients with brain tumors, P carinii pneumonia developed. The median duration of dexamethasone therapy at the onset of P carinii pneumonia symptoms was 2.75 months. Symptoms began during tapering of steroid therapy in eight episodes. Bronchoscopy was diagnostic in the eight cases in which it was performed. Four episodes (40%) were fatal. Trimethoprim-sulfamethoxazole prophylaxis may be indicated in some patients with brain tumors, especially during tapering of steroid therapy.


Jul 10, 2003·Lancet Neurology·Rajiv Sarin, Vedang Murthy
Dec 5, 2003·Lancet·Michail S Lionakis, Dimitrios P Kontoyiannis
Aug 3, 2005·Thorax·R F MillerA E Wakefield
Oct 18, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·P GavianiA Salmaggi
Jul 21, 2005·International Journal of Radiation Oncology, Biology, Physics·Michael A HughesLawrence Kleinberg
Feb 24, 2001·The American Journal of the Medical Sciences·D A Russian, S J Levine
Aug 29, 2012·Critical Reviews in Oncology/hematology·Filip Y De VosCarla M van Herpen
Jul 17, 2012·Hematology/oncology Clinics of North America·Jill LacyJames B Yu
Sep 17, 2011·Revue de pneumologie clinique·C ToperL-J Couderc
Feb 23, 2010·Infectious Disease Clinics of North America·Emilie CatherinotOlivier Lortholary
Oct 30, 2007·Neurologic Clinics·Jan DrappatzPatrick Y Wen
Jul 24, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·S K T Yu, A J Chalmers
Nov 23, 2006·Hematology/oncology Clinics of North America·T Batchelor, Thomas N Byrne
Oct 1, 1993·Cancer Treatment Reviews·I Varthalitis, F Meunier
Feb 1, 1993·The American Journal of Medicine·A SlivkaJ S Loeffler
May 13, 1998·Neurologic Clinics·David SchiffP Y Wen
Jul 6, 2015·Current Treatment Options in Oncology·Jeffrey J Raizer, Karan S Dixit
Nov 2, 2014·Neuro-oncology·David SchiffPatrick Y Wen
Jun 3, 2015·Neuro-oncology Practice·Patrick RothMichael Weller
Aug 24, 2016·The Journal of Antimicrobial Chemotherapy·Catherine CordonnierFifth European Conference on Infections in Leukemia (ECIL-5), a joint venture of The European Group for Blood and Marrow Tra
Feb 1, 2017·Current Neurology and Neuroscience Reports·K Ina Ly, Patrick Y Wen
Dec 30, 2016·JAAPA : Official Journal of the American Academy of Physician Assistants·Nika Pierre-Louis, Brian Dlugos
Mar 8, 2017·Journal of Pediatric Hematology/oncology·Rebecca ProudfootSophie Wilne
Oct 2, 2013·The American Journal of Hospice & Palliative Care·Takashi YamaguchiTakayuki Hisanaga
Mar 20, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Subbulaxmi Trikudanathan, Graham T McMahon
Apr 1, 1994·Journal of Paediatrics and Child Health·Y F CheungY L Lau
Oct 22, 2010·Current Opinion in Neurology·Patrick RothMichael Weller
Jan 1, 1997·Scandinavian Journal of Infectious Diseases·C ArmbrusterS Kriwanek
May 1, 2002·Current Opinion in Oncology·Patrick Y Wen, Peter W Marks
Nov 5, 1997·Journal of Pediatric Hematology/oncology·T LehrnbecherS J Chanock
Dec 24, 1992·The New England Journal of Medicine·H Masur
Jun 15, 2011·Expert Review of Clinical Pharmacology·Jörg DietrichSantosh Kesari
Aug 1, 2020·Current Treatment Options in Oncology·Karan S Dixit, Priya U Kumthekar
Jun 30, 2006·Journal of Neuro-oncology·Patrick Y WenLisa Doherty
Jul 27, 2002·Journal of Pediatric Hematology/oncology·Winston W HuhGeorge R Buchanan
Nov 1, 2008·Journal of Neuro-oncology·Tadeu Ferreira de PaivaDaniel Luiz Gimenes

Related Concepts

Pneumocystis Infections
Pneumocystis Jiroveci Pneumonia
Brain Neoplasms
Opportunistic Infections
Trimethoprim-Sulfamethoxazole Combination
Bronchoscopic Surgical Procedures
Brain Tumor, Primary

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