Pneumocystis jiroveci pneumonia associated with low-dose methotrexate treatment for rheumatoid arthritis: report of two cases and review of the literature

Modern Rheumatology
Yuko KanekoMichito Hirakata

Abstract

Low-dose methotrexate (MTX) therapy is widely used for rheumatoid arthritis (RA) because of its favorable efficacy and toxicity profile. Although Pneumocystis jiroveci pneumonia (PCP) is most often seen in severely immunosuppressed patients, PCP complicating low-dose MTX therapy for RA has been reported to sometimes occur. We herein report two cases of patients who developed PCP during treatment with low-dose MTX, and discuss the importance of prophylaxis for this opportunistic infection.

References

Sep 1, 1990·Clinical and Experimental Dermatology·H Groenendal, F H Rampen
Oct 1, 1983·Arthritis and Rheumatism·J L PerruquetD E Davis
Jul 1, 1994·Annals of the Rheumatic Diseases·P BarreraL B van de Putte
Jul 1, 1994·American Journal of Respiratory and Critical Care Medicine·G P LeMense, S A Sahn
Jan 1, 1994·Scandinavian Journal of Rheumatology·A A StengerH R Pasma
Aug 13, 2002·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·F RoblotB Becq-Giraudon
Aug 27, 2002·Emerging Infectious Diseases·James R StringerAnn E Wakefield
May 26, 2005·Pharmacological Reviews·Bruce N Cronstein

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Citations

Aug 21, 2010·Future Microbiology·Olga Matos, Francisco Esteves
Dec 1, 2007·Journal of Crohn's & Colitis·Dietlind Schleiermacher, Jörg C Hoffmann
Mar 3, 2010·The Journal of Rheumatology·Deanna CettomaiLisa Christopher-Stine
May 4, 2010·The Journal of Rheumatology·Josiane Bourré-Tessier, Boulos Haraoui
Jun 3, 2010·The Journal of Rheumatology·Wanruchada KatchamartUNKNOWN Canadian 3e Initiative Consensus Group
Feb 25, 2011·The Pediatric Infectious Disease Journal·Gemma CrightonTom G Connell

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