Pneumocystis jirovecii pneumonia in solid organ transplant recipients: a descriptive analysis for the Swiss Transplant Cohort

Transplant Infectious Disease : an Official Journal of the Transplantation Society
D NeofytosSwiss Transplant Cohort Study

Abstract

Descriptive data on Pneumocystis jirovecii pneumonia (PJP) in solid organ transplant recipients (SOTr) in the era of routine Pneumocystis-prophylaxis are lacking. All adult SOTr between 2008 and 2016 were included. PJP was diagnosed based on consensus guidelines. Early-onset PJP was defined as PJP within the first-year-post-transplant. 41/2842 SOTr (1.4%) developed PJP (incidence rate: 0.01/1000 person-days) at a mean of 493-days post-transplant: 21 (51.2%) early vs 20 (48.8%) late-onset PJP. 2465 (86.7%) SOTr received Pneumocystis-prophylaxis for a mean 316 days. PJP incidence was 0.001% and 0.003% (log-rank < 0.001) in SOTr with and without Pneumocystis-prophylaxis, respectively. PJP was an early event in 10/12 (83.3%) SOTr who did not receive Pneumocystis-prophylaxis and developed PJP, compared to those patients who received prophylaxis (11/29, 37.9%; P-value: 0.008). Among late-onset PJP patients, most cases (13/20, 65%) were observed during the 2nd year post-transplant. Age ≥65 years (OR: 2.4, P-value: 0.03) and CMV infection during the first 6 months post-SOT (OR: 2.5, P-value: 0.006) were significant PJP predictors, while Pneumocystis-prophylaxis was protective for PJP (OR: 0.3, P-value: 0.006) in the overall population....Continue Reading

References

May 1, 1992·Transplant International : Official Journal of the European Society for Organ Transplantation·C G ElinderG Tydén
Feb 1, 1995·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C HennequinH Kreis
Jun 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S M ArendF J van der Woude
Mar 4, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S M GordonD L Longworth
Sep 21, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J A Fishman
Jan 24, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A HumarUNKNOWN AST ID Working Group on Infectious Disease Monitoring
Jul 9, 2009·Transplantation·Robert T NeffKevin C Abbott
Oct 23, 2009·Kidney International·Bertram L KasiskeEthan M Balk
Nov 13, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Frank EitnerMichael Fischereder
Jun 22, 2011·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M G J de BoerJ T van Dissel
Sep 17, 2011·The European Respiratory Journal·K MühlethalerC Garzoni
Nov 19, 2011·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S AnandD R Kaul
Mar 10, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R U PliquettI A Hauser
Mar 21, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Monica SassiJoseph A Kovacs
May 11, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·E H Z WangE D Greanya
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S I MartinUNKNOWN AST Infectious Diseases Community of Practice
Jul 25, 2014·The American Journal of Medicine·Pierre FillatrePierre Tattevin
Aug 26, 2014·Emerging Infectious Diseases·Antoine RouxÉlie Azoulay
Dec 17, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·X IriartA Berry
Nov 27, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Adrian M EidenBeverly A Mock
Aug 24, 2016·The Journal of Antimicrobial Chemotherapy·Alexandre AlanioUNKNOWN 5th European Conference on Infections in Leukemia (ECIL-5), a joint venture of The European Group for Blood and Marrow Trans
Oct 30, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Per LjungmanUNKNOWN Disease Definitions Working Group of the Cytomegalovirus Drug Development Forum
Sep 28, 2015·Journal of Fungi·Xavier IriartAntoine Berry

❮ Previous
Next ❯

Citations

Apr 17, 2020·Mycoses·Jochem B BuilJacques F Meis
Sep 8, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Jessica LumChristine E Koval
Aug 5, 2019·European Journal of Clinical Pharmacology·Maryam GhadimiAlireza Milajerdi
Apr 12, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Benjamin HanischMonica I Ardura
Mar 27, 2019·Intensive Care Medicine·Jean-François TimsitChristian Van Delden
Jan 10, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Christian van DeldenUNKNOWN Swiss Transplant Cohort Study
Nov 11, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Kathryn PetersonJulie Ho
Oct 23, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carlos CerveraDima Kabbani
Oct 24, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hannah KaminskiPierre Merville
Apr 20, 2021·Expert Opinion on Pharmacotherapy·R Benson WeyantCarlos Cervera
Jun 18, 2021·Respiratory Medicine·D WilmesN Kanaan
Oct 30, 2021·Immunity, Inflammation and Disease·Philip B AndreasenSusanne D Nielsen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
H-Y SunNina Singh
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
S I MartinAST Infectious Diseases Community of Practice
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Alfonso MolinaGary J Schiller
© 2022 Meta ULC. All rights reserved