Pneumocystis pneumonia in a patient treated with pemetrexed for non small cell lung cancer

Revue des maladies respiratoires
M NeuvilleB Crestani


Pneumocystis pneumonia is a life-threatening infection in patients undergoing chemotherapy for solid malignancies. A 49-year-old man developed gradually increasing dyspnoea while receiving pemetrexed as a third line treatment for an adenocarcinoma of the lung. The diagnosis of pneumocystis pneumonia was based on ground-glass opacities on the thoracic CT scan and alveolar lavage revealing occasional cysts of Pneumocystis jiroveci in the context of recent lymphopenia developing during chemotherapy. Treatment with cotrimoxazole for three weeks was only partially successful due to progression of the tumour. Pneumocystis pneumonia should be considered in cancer patients receiving antifolate drugs and presenting with increasing dyspnoea. It is important to identify a high-risk population among patients undergoing chemotherapy because of the significant morbidity and mortality and in order to administer effective prophylactic agents.


May 9, 2012·Expert Opinion on Biological Therapy·Constantin A DasanuNausheen Ahmed


Nov 1, 1980·Chest·B E Fossieck, S V Spagnolo
Mar 1, 1995·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·E van MeertenJ H Schellens
Jul 1, 1994·American Journal of Respiratory and Critical Care Medicine·G P LeMense, S A Sahn
Nov 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K A Sepkowitz
Apr 3, 2003·Cancer Treatment Reviews·Beela S Mathew, Stuart A Grossman
Jun 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alex A Adjei
Apr 3, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Vamsidhar Velcheti, Ramaswamy Govindan
Oct 16, 2007·Chest·Guillaume BolléeElie Azoulay
Oct 8, 2009·Clinical Lung Cancer·Yohann LoriotJean-Charles Soria

Related Concepts

Immunofluorescence Assay
Adenocarcinoma of Lung (Disorder)
Morbidity Aspects
Enzymes, antithrombotic
Antibiotics, Antifungal

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Related Papers

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
Raymond J Enzenauer, Khalid J Khan
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
James A ChessAshraf I Mikhail
© 2020 Meta ULC. All rights reserved