PMID: 15240724Jul 9, 2004Paper

Pneumolysin-induced lung injury is independent of leukocyte trafficking into the alveolar space

The Journal of Immunology : Official Journal of the American Association of Immunologists
U MausJ Lohmeyer

Abstract

Pneumolysin (PLY) is a major virulence factor released by Streptococcus pneumoniae and has been implicated in the pathogenesis of pneumococcal pneumonia. In this study, we evaluated the contribution of newly recruited neutrophils and monocytes and resident alveolar macrophages to the pathogenesis of PLY-induced lung injury. Mice received either adhesion-blocking Abs to inhibit alveolar leukocyte trafficking or liposomal clodronate to deplete alveolar macrophages before intratracheal application of native PLY or its noncytotoxic derivative PdB. We found that treatment with PLY but not PdB resulted in increased lung vascular permeability. In addition, PLY also induced a decrease in the resident alveolar macrophage population, and the recruitment of peripheral blood neutrophils and monocytes into the alveolar space. Blockade of PLY-induced alveolar leukocyte trafficking by pretreatment of mice with anti-CD18 plus anti-CD49d Abs or depletion of circulating neutrophils did not attenuate the increase in lung permeability observed in response to intratracheal PLY. In addition, depletion of resident alveolar macrophages with clodronated liposomes did not reduce alveolar injury developing in response to PLY. PLY-induced lung injury was ...Continue Reading

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Citations

Mar 18, 2006·American Journal of Respiratory Cell and Molecular Biology·Ulrich A MausJürgen Lohmeyer
Apr 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christine WinterUlrich A Maus
Jul 31, 2007·Future Microbiology·Charles Feldman, Ronald Anderson
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Apr 8, 2020·Toxins·Rudolf LucasJürg Hamacher
Apr 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christine WinterUlrich A Maus
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Jul 16, 2015·Scientific Reports·Wujian XuQiang Li
Feb 3, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melissa M WalkerJessy Deshane
May 19, 2018·The European Respiratory Journal·Philippe BonniaudMartin Kolb
Nov 30, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Walter AdamsJohn M Leong
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Jul 17, 2014·American Journal of Respiratory and Critical Care Medicine·István CzikoraRudolf Lucas
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Sep 3, 2021·Infection·Vsevolod A ZinserlingAngelica E Makarova
Nov 5, 2021·Frontiers in Medicine·Hee-Young YoonJin Woo Song

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