Pneumonectomy after neoadjuvant chemotherapy and radiation for advanced-stage lung cancer

Annals of Surgical Oncology
Thomas NgThomas A Dipetrillo

Abstract

Intergroup 0139 Trial suggests an increase in mortality after pneumonectomy in patients receiving preoperative chemotherapy and radiation. We evaluate our outcomes with pneumonectomy after neoadjuvant chemotherapy and radiation. Neoadjuvant chemotherapy and radiation consisted of cisplatin 50 mg/m2 on days 1, 8, 29, and 36 and etoposide 50 mg/m2 on days 1-5 and 29-33 given concurrently with 5,040 cGy radiation. From a prospective database, results after pneumonectomy were compared between patients receiving and not receiving neoadjuvant chemotherapy and radiation during the same time period. Over 7 years, 50 pneumonectomies were performed for non-small-cell carcinoma; 18 received neoadjuvant chemotherapy and radiation (group A) and 32 did not (group B). Comparing group A with group B, there was no significant difference in patient demographics, blood loss, transfusion requirements or pneumonectomy side. Group A had more patients with stage III disease [17/ 18 (94%) versus 15/32 (47%), P = 0.001] and also more often had vascularized flap for bronchial stump coverage [17/18 (94%) versus 4/32 (13%), P < 0.001]. There was no significant difference in operative morbidity or mortality. Mortality for group A was 0/18 and for group B w...Continue Reading

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Citations

Sep 1, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Masatsugu HamajiHiroshi Date
Jul 14, 2016·Journal of Oncology Practice·Sai Yendamuri
Jul 7, 2012·Southern Medical Journal·Rohan J Kalathiya, Sibu P Saha

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