Pneumonectomy for lung cancer after preoperative concurrent chemotherapy and high-dose radiation

The Annals of Thoracic Surgery
Mark KrasnaMohan Suntharalingam

Abstract

We studied the clinical characteristics and outcomes of patients undergoing pneumonectomy after preoperative concurrent chemoradiation for non-small cell lung cancer. Clinical records of patients with non-small cell lung cancer who underwent pneumonectomy at our institution between 1995 and 2005 after preoperative concurrent chemoradiation were reviewed retrospectively. Twenty-nine patients underwent pneumonectomy after preoperative concurrent chemoradiation. Of the 21 men and 8 women who were treated, 1 had stage IIB (T3N0M0) and the remainder had stage IIIA or IIIB non-small cell lung cancer. Mean patient age at surgery was 53.4 years. There were 15 right pneumonectomies, of which 2 were for pancoast tumors. All patients received concurrent preoperative chemoradiation. Mean total radiation dose was 61.1 Gy. All patients went on to have complete (R0) resection by pneumonectomy. Pathologic complete response was found in 16 patients (55.2%). All patients were discharged alive from the hospital after pneumonectomy. Median hospital length of stay was 5 days (mean 8.6). Ninety-day mortality after surgery was 3.4% (n = 1). Recurrences have been found in 11 patients (38%), including brain metastases (n = 6), bone metastases (n = 4), ...Continue Reading

References

Apr 1, 1993·The Annals of Thoracic Surgery·V W Rusch, J R Benfield
Apr 1, 1993·The Annals of Thoracic Surgery·W C FowlerS M Keller
Sep 4, 1999·The Annals of Thoracic Surgery·J R SonettZ Gamliel
Jan 13, 2001·The Annals of Thoracic Surgery·R BuenoD J Sugarbaker
Aug 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kathy S AlbainRobert B Livingston
Jan 15, 2003·Current Treatment Options in Oncology·Martin J EdelmanMark J Krasna
Feb 1, 2005·The Annals of Thoracic Surgery·Gail E DarlingRobert Ginsberg
Aug 2, 2005·The European Respiratory Journal·P Van SchilN van Zandwijk
Sep 27, 2005·The Annals of Thoracic Surgery·Robert James CerfolioAlfred A Bartolucci

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Citations

Apr 6, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Gregory A KuzmikAnthony W Kim
Mar 1, 2014·General Thoracic and Cardiovascular Surgery·Satona TanakaYosuke Otake
Jun 29, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Thomas E StinchcombeRamaswamy Govindan
Aug 13, 2013·Thoracic Surgery Clinics·R Taylor Ripley, Valerie W Rusch
Feb 20, 2013·Revue des maladies respiratoires·P Bonnette
Oct 12, 2011·Surgical Oncology Clinics of North America·Benedict D T DalyMark J Krasna
Oct 12, 2011·Surgical Oncology Clinics of North America·Lyall A Gorenstein, Joshua R Sonett
Jul 2, 2011·The Annals of Thoracic Surgery·Felix G FernandezDaniel L Miller
May 31, 2011·The Annals of Thoracic Surgery·Anthony W KimL Penfield Faber
Feb 2, 2011·The Journal of Thoracic and Cardiovascular Surgery·Benedict D T DalyLisa A Kachnic
Oct 25, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Massimo Di MaioGaetano Rocco
Jun 17, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·D ShumwayJ K Salama
Jul 1, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·C DickhoffM Dahele
Jun 5, 2016·Surgical Oncology Clinics of North America·David J SugarbakerOri Wald
Jul 19, 2016·Thoracic Surgery Clinics·Erin A Gillaspie, Dennis A Wigle
Sep 23, 2016·Japanese Journal of Clinical Oncology·Kazuhiko Shien, Shinichi Toyooka
Feb 27, 2014·Asian Cardiovascular & Thoracic Annals·Rohan J KalathiyaSibu P Saha
Aug 21, 2016·Interactive Cardiovascular and Thoracic Surgery·Yoshihisa ShimadaNorihiko Ikeda
Feb 9, 2021·Annals of Plastic Surgery·Malke AsaadSteven L Moran

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