PMID: 6965334Jan 1, 1980Paper

Pneumonia during therapy for childhood acute lymphoblastic leukemia

American Journal of Diseases of Children
S E SiegelG D Hammond

Abstract

The incidence of pneumonia was evaluated in 844 children undergoing initial treatment for acute lymphoblastic leukemia (ALL). A total of 310 episodes occurred in 239 patients followed up for five to 36 months after diagnosis. The peak incidences occurred in the periods 0 to 20 days and 40 to 80 days after the start of antileukemic therapy. Bacterial pneumonias occurred primarily during the first 20 days after diagnosis of ALL. No episode of Pneumocystis carinii pneumonia was noted before 40 days, and the majority of instances occurred 50 to 120 days after diagnosis. In 80% of all episodes, a specific causative organism was not detected. The incidence of P carinii pneumonia was greater in patients receiving intrathecal methotrexate as part of CNS prophylaxis than in those receiving only CNS irradiation. Pneumonia is a frequent event during the therapy of ALL in childhood.

Citations

Feb 1, 1987·Archives of Disease in Childhood·M P GerrardA W Craft
Nov 1, 1981·Archives of Disease in Childhood·J Ninane, J M Chessells
Nov 8, 1980·British Medical Journal
Mar 18, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·V MicheliG Pompucci
Aug 23, 2011·European Journal of Haematology·Mette LevinsenUNKNOWN Nordic Society of Paediatric Haematology and Oncology (NOPHO)
Dec 1, 1983·Journal of Pediatric Surgery·E ImokeJ A Haller
Aug 24, 2016·The Journal of Antimicrobial Chemotherapy·Catherine CordonnierUNKNOWN Fifth European Conference on Infections in Leukemia (ECIL-5), a joint venture of The European Group for Blood and Marrow Tra

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