PMID: 9422174Mar 1, 1995Paper

Pneumonia in ventilated head trauma patients: the role of thiopental therapy

European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine
P NadalS Nogué

Abstract

The role of barbiturate therapy in the development of pneumonia in head trauma patients in the intensive care unit of a university hospital was studied retrospectively. A total of 151 ventilated head trauma patients were included in the study. Intravenous thiopentone was administered to 75 patients (Group A), and 76 patients were managed without thiopentone therapy (Group B). Pneumonia was diagnosed when a new persistent pulmonary infiltrate appeared, with at least two of the following: (a) fever greater than 38 degrees C, (b) a white blood cell count greater than 15,000/mm3, or (c) the presence of purulent bronchial secretions. On admission, there were no differences in the acute physiology and chronic health evaluation 2 revision (APACHE II) and Glasgow Coma Score between Groups A and B. Fifty-three per cent of the patients treated with thiopentone (Group A) developed pneumonia compared with 35% in Group B (odds ratio 1.85, 95% confidence interval 0.97-3.51). Gram-negative and Staphylococcus aureus organisms were the most frequently isolated in all cases. No differences in age, sex, APACHE II, Glasgow Coma Score, nutritional status or dexamethasone treatment were observed between the groups with and without pulmonary infectio...Continue Reading

Citations

Mar 13, 2013·Nature Reviews. Neurology·Bertil Romner, Per-Olof Grände
Mar 17, 2010·Critical Care : the Official Journal of the Critical Care Forum·Saad NseirCharles-Hugo Marquette
Mar 11, 2011·PloS One·Daniel W WheelerJohn S Beech
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