Pneumonitis from immune checkpoint inhibitors and COVID-19: current concern in cancer treatment

Journal for Immunotherapy of Cancer
Ernesto RossiGiampaolo Tortora

Abstract

Pneumonitis is a rare but serious adverse event caused by cancer immunotherapy. The diagnosis between COVID-19-induced pneumonia and immunotherapy-induced pneumonitis may be challenging in the era of COVID-19 outbreak. Some clinical symptoms and radiological findings of pneumonitis can be attributed to the coronavirus infection as well as to an immune-related adverse event. Identifying the exact cause of a pneumonitis in patients on treatment with immunotherapy is crucial to promptly start the most appropriate treatment. The proper management of immune checkpoint inhibitors for the risk of pneumonia must take into account a series of parameters. Accurate attention should be payed to symptoms like cough, fever and dyspnea during immunotherapy.

References

Sep 21, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jarushka NaidooMatthew D Hellmann
Jun 5, 2019·The American Journal of Surgical Pathology·Brandon T LarsenAnja C Roden
Mar 3, 2020·Journal of Autoimmunity·Hussin A Rothan, Siddappa N Byrareddy
May 1, 2020·Nature Medicine·Quan-Xin LongAi-Long Huang
May 1, 2020·AJR. American Journal of Roentgenology·Shuchang Zhou, Gang Wu

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Citations

Nov 2, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Emre YekedüzYüksel Ürün
Feb 6, 2021·Expert Opinion on Biological Therapy·Parmida Sadat Pezeshki, Nima Rezaei
Dec 29, 2020·Cancer Investigation·Nicole M Kuderer, Gary H Lyman
Aug 27, 2021·Frontiers in Oncology·Ewa KalinkaKamila Wojas-Krawczyk

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Methods Mentioned

BETA
PCR

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