PMID: 9192938Jun 1, 1997Paper

Pneumothorax in HIV-infected patients: role of Pneumocystis carinii pneumonia and pulmonary tuberculosis

The European Respiratory Journal
M TumbarelloL Ortona

Abstract

Patients with acquired immune deficiency syndrome (AIDS) are at increased risk for pneumothorax, which usually occurs in the setting of Pneumocystis carinii pneumonia. The rationale of the present study was based on the hypothesis that the increased incidence of pulmonary tuberculosis in human immunodeficiency virus (HIV)-infected patients could favour the development of pneumothorax in such patients. A case-control study was performed comprising 140 HIV-infected patients grouped as follows: 35 patients with pneumothorax and 105 matched controls without pneumothorax. Univariate analysis identified four risk factors for pneumothorax: 1) previous P. carinii pneumonia (p=0.01); 2) current P. carinii pneumonia (p=0.02); 3) pulmonary tuberculosis (p=0.01); and 4) cysts, pneumatoceles or bullae on chest radiographs (p<0.001). Multivariate analysis indicated that current P. carinii pneumonia (p=0.01) and pulmonary tuberculosis (p=0.04) were both independent risk factors for pneumothorax. In conclusion, our findings demonstrate that, in addition to Pneumocystis carinii pneumonia, pulmonary tuberculosis enhances the risk of pneumothorax in patients with acquired immune deficiency syndrome.

Associated Clinical Trials

Citations

Jul 27, 2001·Current Opinion in Pulmonary Medicine·B Afessa
Jul 11, 2007·Postgraduate Medical Journal·Graeme P CurrieJoe S Legge
Apr 17, 2009·World Journal of Gastroenterology : WJG·James C LeeTariq Ahmad
Jan 31, 2014·Archives of Pathology & Laboratory Medicine·Frank SchneiderKevin O Leslie
Mar 15, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Mark J Rosen
Dec 4, 2003·Journal of Clinical Pharmacy and Therapeutics·S NatschJ W M van der Meer
Oct 20, 2020·Respiratory Medicine Case Reports·Ambreen Iqbal MuhammadSamiha Naureen
May 24, 2006·Clinics in Chest Medicine·John C English, Kevin O Leslie

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