PNPLA3 Association with Alcoholic Liver Disease in a Cohort of Heavy Drinkers

Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism
Bhanu Prakash KollaVictor M Karpyak

Abstract

Prior studies have established variation at the PNPLA3 gene to be associated with a risk of developing alcoholic liver disease (ALD). We attempt to replicate this finding and other potential genetic variations previously associated with ALD utilizing a case-control design in a cohort of subjects with alcohol use disorders. This case-control study performed in a US clinical sample of heavy drinkers, replicates the previously reported association between ALD and rs738409 polymorphism in the PNPLA3 gene in heavy drinkers. This association persisted after accounting for the subject's diabetes status. Patients of European ancestry with a history of ALD were identified (n = 169). Controls consisted of patients without ALD who were from the same cohorts and were ≥ 30 years of age, had lifetime total years drinking ≥20 and lifetime maximum drinks per day ≥12 (n = 259). Patients were genotyped for 40 candidate single nucleotide polymorphisms (SNPs) selected for the purpose of testing their association with ALD. The association of each SNP with ALD was tested using a logistic regression model, assuming log-additive allele effects. Bonferroni correction was applied and multivariable logistic regression models were used to account for rele...Continue Reading

References

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Citations

Jun 5, 2019·International Journal of Molecular Sciences·Ling-Zu KongTaeho Kwon
Nov 6, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Haizhen ChenJing Huang

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