PNPLA3 rs738409 underlies treatment response in nonalcoholic fatty liver disease

World Journal of Clinical Cases
Jin-Zhi WangQin Pan

Abstract

Non-alcoholic fatty liver disease (NAFLD) has now become the leading cause of chronic liver disease with its growing incidence worldwide. Patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409 C > G reflects one of the critical genetic factors that confers high-risk to NAFLD. However, the role of PNPLA3 polymorphism in NAFLD treatment remains uncertain. Here, the present review reveals that NAFLD patients with G-allele at PNPLA3 rs738409 (PNPLA3 148M variant) are sensitive to therapies of lifestyle modification, dipeptidyl peptidase-4 inhibitors, and bariatric surgery. They exhibit much significant reduction of liver fat content, in concurrence with weigh loss and abolished insulin resistance, as compared to those of C-allele carriers. In contrast, patients bearing PNPLA3 rs738409 C-allele (PNPLA3 148I variant), instead of G-allele, demonstrate greater beneficial effects by omega-3 poly-unsaturated fatty acids and statin intervention. Improved adipose tissue-liver interaction and decrease in intrahepatic triglyceride efflux may contribute to the PNPLA3 rs738409 related diversities in therapeutic efficacy. Therefore, PNPLA3 rs738409 underlies the response to a variety of treatments, which warrants a personalize...Continue Reading

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Citations

Jan 9, 2019·Obesity Surgery·Iraklis PerysinakisElias Margaris
Jan 3, 2019·Current Opinion in Clinical Nutrition and Metabolic Care·Melinda H Spooner, Donald B Jump
Mar 2, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhen HuangYan-Zhou Zhang
Jan 3, 2020·Journal of Gastroenterology and Hepatology·Kana DaijoKazuaki Chayama
Mar 15, 2020·International Journal of Molecular Sciences·Yoshio SumidaJapan Study Group Of Nafld Jsg-Nafld
Feb 6, 2019·Therapeutic Advances in Gastroenterology·Xiao Jing Iris Wang, Michael Camilleri
Jan 14, 2021·Hepatology Communications·Leah R DeCosteMichelle T Long

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Methods Mentioned

BETA
biopsy
gastric bypass
pharmacotherapy

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