PMID: 3756479Aug 20, 1986Paper

pO2-dependent distribution of potassium in hippocampal slices of the guinea pig

Brain Research
H G Lipinski, D Bingmann

Abstract

The distribution of extracellular K+-concentration (cK+s) in 200-1000-micron thick hippocampal slices was studied with ion-selective microelectrodes. In ca. 500-micron thick slices cK+s increased from the surface to the innermost layers by ca. 2 mmol/liter if the pO2 of the bath (pBO2) ranged from 300-600 mm Hg and if the temperature was 28 degrees C. In thicker slices and lowered pO2-values further elevations of cK+s were observed. In vital slices thinner than 500 micron cK+s-values exceeded the potassium-concentration of the bath (cK+B) only when pBO2 was markedly lowered. When pBO2 was reincreased in such thin slices, cK+s rapidly declined and often decreased transiently below ck+B. Similar undershoots of cK+s were observed when cK+B was lowered from high to normal levels. The rapid decline was blocked by hypoxia, ouabain, antimycine and a temperature of 18 degrees C. A stepwise rise of cK+B also caused rapid changes of cK+s in vital thin slices. The rates of changes, however, were hardly affected e.g. by a transient hypoxia. Diffusion did not contribute significantly to these steep changes of cK+s. These rapid distribution modes were widely missing in slices thicker than 500 micron. Therefore in such preparations, the extra...Continue Reading

References

May 1, 1977·Microvascular Research·I A Silver
Sep 1, 1977·Journal of Neurophysiology·B A VernL E Thibault
Sep 14, 1979·Brain Research·J GarthwaiteR Balazs
Feb 1, 1978·The Journal of Physiology·C N Scholfield
Jan 1, 1975·Annual Review of Physiology·G G Somjen
Aug 16, 1974·Brain Research·J A HarveyD A Brown
Jan 1, 1971·Experimental Brain Research·P AndersenK K Skrede
Jul 1, 1984·Journal of Neurophysiology·C P Taylor, F E Dudek
Jul 1, 1982·Acta Physiologica Scandinavica·A J HansenH Jahnsen
Jul 1, 1983·Journal of Neuroscience Methods·J L MunozJ A Coles
Feb 13, 1984·Brain Research·J BagustG A Kerkut
Feb 1, 1983·The Journal of Physiology·A R Gardner-Medwin, C Nicholson
Jul 1, 1983·The Journal of Physiology·J Hounsgaard, C Nicholson
Jan 1, 1982·Experimental Brain Research·D Bingmann, G Kolde
Apr 7, 1980·Brain Research·C BenningerD A Prince
Jul 1, 1980·Brain Research Bulletin·T J Teyler

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Citations

Feb 1, 1988·Journal of Neuroscience Methods·H J RomijnJ M Ruijter
May 1, 1989·Journal of Neuroscience Methods·G C NewmanP Wu
Apr 1, 1992·Journal of Neuroscience Methods·H G Lipinski
Nov 11, 1991·Neuroscience Letters·D BingmannD Ballantyne
Dec 1, 1995·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R E BakerG Widman
Jan 8, 1999·Brain Research·R GutiérrezU Heinemann
Sep 23, 2000·Journal of Neuroscience Methods·D BingmannW Wittkowski
Jul 15, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C S PatlakG C Newman
Jul 14, 2010·Journal of Biomedicine & Biotechnology·Tarek El-NaggarMaría Emilia Carretero
Feb 24, 2016·Journal of Computational Neuroscience·Bartholomew J BacakYaroslav I Molkov
May 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G C NewmanS L Schissel
Sep 1, 1989·The European Journal of Neuroscience·J. De VenteH. W. M. Steinbusch
Dec 1, 1988·Journal of Neurochemistry·G C NewmanC S Patlak
Jan 25, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sabina HrabetováCharles Nicholson
Jul 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G C NewmanC S Patlak
Aug 1, 1989·Physics in Medicine and Biology·H G Lipinski

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