Pocketed Microneedles for Drug Delivery to the Skin.

The Journal of Physics and Chemistry of Solids
Harvinder S Gill, Mark R Prausnitz

Abstract

Drug delivery to the skin is limited by the strong barrier properties of skin's outer layer of stratum corneum. Micron-scale needles have been developed to deliver drugs across this barrier layer and into the skin in a minimally invasive manner. One method of delivery involves coating these microneedles with a drug that rapidly dissolves off within the skin. As a variation on this approach, this study examines microneedles with holes cut through their shafts to form "pockets" that can be filled with drug formulations using a dip-coating method. Our results (i) demonstrated the filling of microneedle pockets having a variety of different sizes and shapes, (ii) quantified the amount of drug that can be filled into pockets and coated onto microneedle surfaces, (iii) developed composite microneedle structures that sequester one model drug within the microneedle pocket and coat another model drug on the microneedle surface and (iv) showed that pocketed microneedles can deliver a model drug to a targeted depth within the skin. We conclude that pocketed microneedles offer unique capabilities for controlled drug delivery to the skin.

References

Mar 26, 2004·Nature Reviews. Drug Discovery·Mark R PrausnitzRobert Langer
Dec 16, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Harvinder S Gill, Mark R Prausnitz
Mar 27, 2007·Pharmaceutical Research·Harvinder S Gill, Mark R Prausnitz

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Citations

Nov 4, 2008·Pharmaceutical Research·Jason JiangMark R Prausnitz
Jul 17, 2013·Advanced Drug Delivery Reviews·Eric Nuxoll
Apr 25, 2014·The AAPS Journal·Koen van der MaadenJoke Bouwstra
Jun 4, 2013·Advanced Drug Delivery Reviews·Nam-Trung NguyenDinh-Tuan Phan
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Apr 24, 2012·Drug Development and Industrial Pharmacy·Jaspreet Singh KochharLifeng Kang
Mar 20, 2010·Drug Delivery·Ryan F DonnellyA David Woolfson
Jun 4, 2014·Journal of Drug Targeting·H KhanZ Ahmad
Jul 2, 2011·Journal of Pharmaceutical Sciences·Qing WangKyriakos D Papadopoulos
May 12, 2012·Advanced Drug Delivery Reviews·Yeu-Chun KimMark R Prausnitz
Feb 22, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Koen van der MaadenJoke Bouwstra
Sep 25, 2015·The Journal of General Virology·Jiafen HuNeil D Christensen
Dec 14, 2011·The Journal of Pharmacy and Pharmacology·Shital H BariyaOm Prakash Sharma
Nov 28, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·B M TorrisiS A Coulman
Jan 15, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Bao-Zhong WangRichard W Compans
Nov 13, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ya GaoPeng Xue
Oct 31, 2019·Dose-response : a Publication of International Hormesis Society·Xiaoxiang HeDaming Wu
Feb 18, 2020·Current Pharmaceutical Biotechnology·Pablo S CastañedaJosé J Escobar-Chávez

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