Podocyte Antigen Staining to Identify Distinct Phenotypes and Outcomes in Membranous Nephropathy: A Retrospective Multicenter Cohort Study.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Nicolas HansetUCLouvain Kidney Disease Network

Abstract

Membranous nephropathy (MN) is characterized by the deposition of immune complexes along glomerular basement membranes. M-Type phospholipase A2 receptor (PLA2R), thrombospondin type 1 domain-containing 7A (THSD7A), exostosin 1 and 2 (EXT1/2), and neural epidermal growth factor-like 1 protein (NELL-1) have been identified as established or potential podocyte antigens in MN. We investigated the association of podocyte antigen staining with MN clinical phenotype and outcomes. Multicenter retrospective cohort study. 177 consecutive patients with MN unrelated to lupus erythematosus, identified after screening of 3,875 native kidney biopsies performed in the Belgian UCLouvain Kidney Disease Network from 2000 through 2018. Positive immunostaining for podocyte antigens on archived kidney biopsy samples. Association with different phenotypes (baseline characteristics of patients and pathologic findings on kidney biopsy), time to cancer and to kidney failure. Kaplan-Meier estimates and Cox regression analyses to assess time to cancer and kidney failure. 177 patients were followed up for a median of 4.0 (IQR, 1.3-8.0) years. Diagnosis of PLA2R-positive (PLA2R+), THSD7A+, and double-negative (PLA2R-/THSD7A-) MN was made in 117 (66.1%), 6 (...Continue Reading

Citations

Mar 7, 2021·Mayo Clinic Proceedings·Shane A BobartAn S De Vriese
Jan 23, 2021·Current Opinion in Nephrology and Hypertension·Pierre Ronco, Hanna Debiec
Apr 10, 2021·Journal of the American Society of Nephrology : JASN·Sanjeev SethiPierre Ronco
Aug 3, 2021·Journal of Immunology Research·Pingna ZhangWeijing Liu
Oct 2, 2021·Nature Reviews. Disease Primers·Pierre RoncoJack Wetzels

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