Podocyte GTPases regulate kidney filter dynamics.

Kidney International
Andreas D KistlerJochen Reiser

Abstract

Our concept of the kidney filtration barrier is changing from one of a static sieve into one of a highly dynamic structure regulated through the motility of podocyte foot processes. Inactivation of the small GTPase RhoA in vitro causes hypermotility, whereas activation decreases motility. Wang et al. show that both overactivation and underactivation of RhoA lead to podocyte foot process effacement and proteinuria in vivo. These data suggest that podocyte health requires a well-controlled balance between the two extremes.

References

Dec 13, 2002·Nature·Sandrine Etienne-Manneville, Alan Hall
Aug 21, 2009·Nature·Matthias MachacekGaudenz Danuser
Nov 20, 2009·Kidney International·Peter Mundel, Jochen Reiser
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Aug 2, 2011·Nature Medicine·Changli WeiJochen Reiser
Jan 27, 2012·Kidney International·Liming WangRobert F Spurney

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Citations

Oct 9, 2013·Nature Medicine·Jochen Reiser
Jan 9, 2013·Nature Reviews. Nephrology·Miki Nagase, Toshiro Fujita
Nov 8, 2012·Current Opinion in Nephrology and Hypertension·Michal Herman-EdelsteinUzi Gafter
Jan 9, 2013·Journal of Innate Immunity·Michifumi YamashitaSteven N Emancipator
Jul 23, 2013·The Journal of Clinical Investigation·Heon Yung GeeFriedhelm Hildebrandt
Apr 5, 2013·Journal of Cellular Biochemistry·Guiying LiTieying Shan
Oct 18, 2014·Frontiers in Endocrinology·Carl James MayGavin Iain Welsh
Mar 24, 2018·Scientific Reports·Rin AsaoKatsuhiko Asanuma
Oct 11, 2017·Journal of the American Society of Nephrology : JASN·Sylvia CechovaThu H Le
Mar 16, 2018·Scientific Reports·Ryo HatanoShinji Asano
Jul 29, 2017·Scientific Reports·James C McCaffreyRachel Lennon
Apr 3, 2020·Experimental & Molecular Medicine·Seyoung YuHeon Yung Gee
Jan 8, 2020·International Journal of Molecular Sciences·Ashish K SolankiEhtesham Arif
Jul 28, 2020·Cells·Judith Blaine, James Dylewski
May 2, 2018·Frontiers in Medicine·Yumeng WenKirk N Campbell
Jul 10, 2018·The Journal of Clinical Investigation·Kayaho MaedaGeorge C Tsokos
Nov 15, 2019·F1000Research·Moin A Saleem, Gavin I Welsh
Feb 23, 2021·KI Reports·Youying MaoFriedhelm Hildebrandt
Jun 18, 2021·Small GTPases·Clara SteichenNicolas Bourmeyster

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Methods Mentioned

BETA
GTPases
transgenic

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