PMID: 9639039Jun 25, 1998Paper

Podocyte phenotypes as defined by expression and distribution of GLEPP1 in the developing glomerulus and in nephrotic glomeruli from MCD, CNF, and FSGS. A dedifferentiation hypothesis for the nephrotic syndrome

Experimental Nephrology
K SharifR C Wiggins

Abstract

Glomerular epithelial protein 1 (GLEPP1) is a podocyte receptor membrane protein tyrosine phosphatase located on the apical cell membrane of visceral glomerular epithelial cell (VGEC) foot processes. Double label immunofluorescence, immunoelectron microscopy, and peroxidase immunohistochemistry were used to map the GLEPP1 distribution in the developing glomerulus and in minimal-change nephropathy (MCN), congenital nephrotic syndrome of the Finnish type, and focal-segmental glomerulosclerosis (FSGS). In MCN GLEPP1 was shifted away from the glomerular basement membrane on the apical cell membrane of effaced foot processes. These data are compatible with the previously suggested concept that MCN can be considered a form of dedifferentiation of the podocyte phenotype. Similarly, changes seen in congenital nephrotic syndrome of the Finnish type can be considered a consequence of failure to complete normal podocyte development. In FSGS glomeruli GLEPP1 was frequently absent from VGECs, even when no sclerosis was detectable in that glomerulus. Therefore, in FSGS, VGECs may lose GLEPP1, and this loss appears to occur in the absence of scarring and may, therefore, precede the scarring process. We speculate that a changed VGEC phenotype ...Continue Reading

Citations

Jul 4, 2001·The Journal of Experimental Medicine·R DoyonnasK M McNagny
Jul 31, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jocelyn E Wiggins
May 1, 2009·American Journal of Physiology. Renal Physiology·Deane S CharbaVirginia J Savin
Oct 16, 2008·Kidney International·Amy K MottlKari E North
Dec 17, 2009·Seminars in Nephrology·Jocelyn Wiggins
Jan 19, 2012·Renal Failure·Dong SunLi Meng
Jun 28, 2007·The Journal of International Medical Research·J TianJ Hua Chen
Oct 27, 2017·Current Opinion in Nephrology and Hypertension·Pedro Geraldes
Dec 2, 2009·The Journal of Pathology·Gavin I Welsh, Moin A Saleem
Apr 17, 2008·Critical Reviews in Clinical Laboratory Sciences·Vladimír Tesar, Tomás Zima
Sep 24, 1999·Current Opinion in Nephrology and Hypertension·W Kriz, K V Lemley
Jun 10, 2000·Current Opinion in Nephrology and Hypertension·A B Fogo
Mar 20, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Abhay N VatsMichael Mauer
Jun 1, 2002·Journal of the American Society of Nephrology : JASN·Marcus J MoellerLawrence B Holzman
Oct 22, 2003·Journal of the American Society of Nephrology : JASN·Holger SchmidMatthias Kretzler
Feb 7, 2001·Journal of the American Society of Nephrology : JASN·Jean BariétyAlain Meyrier
Oct 31, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·L V IvanovaD Proppe
Mar 6, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Prasad Devarajan, Adrian Spitzer

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