Podocytes present antigen to activate specific T cell immune responses in inflammatory renal disease

The Journal of Pathology
Shan LiKe Zen

Abstract

Infiltration of activated T cells into renal tissue plays an essential role in inflammatory nephropathy. However, the mechanism enabling the renal recruitment and activation of T cells remains elusive. Here we report that inflammatory cytokine-promoted antigen presentation by podocytes is a key for recruiting and activating specific T cells. Our results showed that diabetes-associated inflammatory cytokines IFNγ and IL-17 all upregulated expression of MHC-I, MHC-II, CD80 and CD86 on podocyte surface. Both IFNγ and IL-17 stimulated the uptake and processing of ovalbumin (OVA) by mouse podocytes, resulting in presentation of OVA antigen peptide on cell surface. OVA antigen presentation by podocytes was also validated using human podocytes. Furthermore, OVA antigen-presenting mouse podocytes were able to activate OT-I mouse T cell proliferation and inflammatory cytokine secretion, which in turn, caused podocyte injury and apoptosis. Finally, OT-I mice subjected to direct renal injection of OVA plus IFNγ/IL-17 but not OVA alone exhibited OVA antigen presentation by podocytes and developed nephropathy in 4 wk. In conclusion, antigen presentation by podocytes under inflammatory condition plays an important role in activating T cell i...Continue Reading

References

Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P S JatD Kioussis
May 1, 1988·Diabetes·J J BendingG C Viberti
Jan 14, 1994·Cell·K A HogquistF R Carbone
Jul 31, 1996·Mechanisms of Ageing and Development·D LioC Caruso
Dec 9, 1997·The Journal of Laboratory and Clinical Medicine·R S FifeG W Sledge
May 18, 2004·The Journal of Clinical Investigation·Jochen ReiserPeter Mundel
Feb 8, 2008·Journal of the American Society of Nephrology : JASN·Miriam C BanasCharles E Alpers
Jun 18, 2010·American Journal of Physiology. Renal Physiology·Hidetake KuriharaTatsuo Sakai
Jan 31, 2012·American Journal of Nephrology·Ju-Young MoonSang-Ho Lee
Oct 11, 2012·Bioscience, Biotechnology, and Biochemistry·Haruyo Nakajima-AdachiSatoshi Hachimura
Mar 30, 2013·Journal of the American Society of Nephrology : JASN·Andreas GoldwichAndré Gessner
Nov 22, 2013·Nanotoxicology·Weimin ChenNorbert E Kaminski
Apr 23, 2014·Molecular and Cellular Biology·Hortensia de la FuenteFrancisco Sánchez-Madrid
Jul 6, 2014·The New England Journal of Medicine·Lakhmir S ChawlaPaul L Kimmel
Apr 29, 2015·The Journal of Clinical Investigation·Jun-Jae ChungAndrey S Shaw
Jun 7, 2015·Journal of the American Society of Nephrology : JASN·Poh-Yi GanStephen R Holdsworth
Sep 18, 2015·Journal of the American Society of Nephrology : JASN·Qi CaoDavid C H Harris
Jun 12, 2016·Journal of the American Society of Nephrology : JASN·Sandeep K MallipattuJohn C He
Jul 22, 2016·American Journal of Physiology. Renal Physiology·Marcela HerreraCarol Moreno Quinn
Dec 22, 2016·Kidney International·Sebastian S RoederStuart J Shankland
Jan 12, 2017·Journal of the American Society of Nephrology : JASN·Daigo NakazawaHans-Joachim Anders
Feb 12, 2017·Kidney International·Jun-Tao YuMing-Hui Zhao
Feb 9, 2018·Nature Reviews. Rheumatology·Hans Ulrich SchererRene E M Toes
Aug 26, 2018·Journal of the American Society of Nephrology : JASN·Yiqing GuoSandeep K Mallipattu
Jan 24, 2019·American Journal of Physiology. Renal Physiology·Giuseppe Stefano NettiGiuseppe Grandaliano
Oct 28, 2019·Frontiers in Pharmacology·Vinicius Andrade-OliveiraNiels Olsen Saraiva Câmara

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Citations

Jul 27, 2021·Cell and Tissue Research·Melissa C SteinMadeleine J Bunders

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