Podocytes … What's Under Yours? (Podocytes and Foot Processes and How They Change in Nephropathy)

Frontiers in Endocrinology
Chris R Neal

Abstract

Most of the described structures of podocytes in health and disease have been inferred from light and electron microscopic studies of rodent models. The variation in filtration barrier features is measured on micrographs, the aim being statistical significance. This is the technical campaign waged against kidney disease but this approach can be misleading. The signaling cascades and connectivity of the podocyte and foot processes (FPs) are inferred from in vitro studies that at best blurr the reality of the in vivo state. This review will outline actin signaling connectivity and the key differences in the structural and functional domains squeezed into the FPs and the relationship of these domains to other parts of the podocyte. It covers the changes in podocytes during nephropathy concentrating on FP and finally proposes an alternative interpretation of FP ultrastructure derived from articles published over the last 60 years.

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Citations

Oct 7, 2015·Frontiers in Endocrinology·Barbara LewkoMaciej Jankowski
Jun 7, 2018·American Journal of Physiology. Renal Physiology·Albert YeeAndrey V Cybulsky
Dec 6, 2018·Journal of the American Society of Nephrology : JASN·Koichiro IchimuraTatsuo Sakai
Apr 11, 2019·Cell Biology International·Patrycja Rachubik, Agnieszka Piwkowska
Dec 28, 2019·Cells·Gentzon HallRobert F Spurney
May 27, 2020·Cellular and Molecular Life Sciences : CMLS·Leticia Labat-de-Hoz, Miguel A Alonso
Oct 22, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Susana RodriguezG William Wong
Jul 16, 2017·Kidney International·Gentzon Hall, Robert F Spurney

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Methods Mentioned

BETA
GTPase
genetic modification
GTPases
transgenic

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