Podocytopenia and disease severity in IgA nephropathy

Kidney International
Kevin V LemleyBryan D Myers

Abstract

IgA nephropathy is a common form of progressive glomerular disease, associated with proliferation of mesangial cells and mesangial deposition of IgA. The present study was designed to investigate functional and morphological covariates of disease severity in patients with IgA nephropathy. Glomerular hemodynamics, permselectivity and ultrastructure were studied in 17 adult patients with IgA nephropathy using inulin, para-aminohippuric acid (PAH) and 3H-Ficoll clearances and morphometric methods. A mathematical model of macromolecule permeation through a heteroporous membrane was used to characterize glomerular permselectivity. Controls consisted of 14 healthy living kidney donors and 12 healthy volunteers. The patients were heterogeneous in their disease severity, but as a group had a decreased glomerular filtration rate (GFR) and increased urinary protein excretion compared to controls [63 +/- 29 SD vs. 104 +/- 23 mL/min/1.73 m2, P < 0.001, and (median) 1.34 vs. 0.11 g/day, P < 0.0001, respectively). A multivariate analysis of structural and functional relationships revealed GFR depression to be most strongly correlated with the prevalence of global glomerular sclerosis (t = -4.073, P = 0.002). Those patients with the most seve...Continue Reading

References

Jan 1, 1979·Journal of Microscopy·E B JensenR Osterby
Sep 1, 1988·Diabetes·Y Nakamura, B D Myers
Mar 1, 1987·Kidney International·E W RauterbergE Ritz
Nov 1, 1972·The American Journal of Physiology·W M DeenB M Brenner
May 1, 1974·Biophysical Journal·W M DeenB M Brenner
Apr 1, 1982·Kidney International·Y S Kanwar, L J Rosenzweig
Aug 1, 1993·The Journal of Clinical Investigation·B S DanielsT H Hostetter
Apr 1, 1995·Kidney International·W LaurensA Remuzzi
Jun 1, 1994·Kidney International·D Kees-FoltsG F Schreiner
Sep 1, 1994·The Journal of Clinical Investigation·M C DrumondW M Deen
Jan 1, 1997·Kidney International·G RemuzziA Benigni
Jan 15, 1997·The Journal of Clinical Investigation·M E PagtalunanT W Meyer
Aug 11, 1998·Journal of the American Society of Nephrology : JASN·A SquarerB D Myers
Sep 12, 1998·Kidney International·W KrizK V Lemley
Sep 24, 1999·Current Opinion in Nephrology and Hypertension·W Kriz, K V Lemley
Apr 7, 2000·Journal of the American Society of Nephrology : JASN·Yoshiki MoritaSeiichi Matsuo
Oct 29, 2000·Journal of the American Society of Nephrology : JASN·Kevin V LemleyRobert G Nelson

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Citations

Feb 3, 2011·Cell and Tissue Research·Thomas Weide, Tobias B Huber
Mar 31, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kevin V Lemley
Mar 6, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kevin V Lemley
Jun 29, 2013·The International Journal of Biochemistry & Cell Biology·Toshiyuki Imasawa, Rodrigue Rossignol
May 25, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lan XuJi Ma
Sep 13, 2003·Kidney International·Arndt T PetermannStuart J Shankland
Mar 13, 2003·Kidney International·Giuseppe D'Amico, Claudio Bazzi
Mar 3, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kathryn E WhiteUNKNOWN Diabiopsies Study Group
Aug 8, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kar Neng LaiSydney C W Tang
Apr 17, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bernd HohensteinChristian P M Hugo
Jan 12, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jiro ToyonagaMitsuo Iida
Aug 7, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Akihiro FukudaRoger C Wiggins
Nov 13, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Fumiko KodamaYasuhiko Tomino
Apr 13, 2006·Current Opinion in Nephrology and Hypertension·Carla ZojaGiuseppe Remuzzi
Mar 21, 2009·Current Opinion in Nephrology and Hypertension·Candice A Roufosse, H Terence Cook
Mar 12, 2008·Current Opinion in Pediatrics·John T Sanders, Robert J Wyatt
Aug 14, 2009·Clinical and Experimental Pharmacology & Physiology·Naro OhashiHiroyuki Kobori
Oct 2, 2004·Kidney International·Paul TrevillianMichael V Agrez
Oct 2, 2004·Kidney International·Vincenzo SepeAntonio Dal Canton
Sep 17, 2005·Kidney International·Takehiko WadaStuart J Shankland
Sep 17, 2005·Kidney International·Kamal F Badr
Mar 9, 2005·Kidney International. Supplement·Kar Neng LaiJoseph C K Leung
Jan 28, 2005·Kidney International·Wilhelm Kriz, Michel LeHir
Jul 30, 2010·American Journal of Physiology. Renal Physiology·Toru SakairiJeffrey B Kopp
Nov 6, 2009·American Journal of Physiology. Renal Physiology·Aurélie Edwards
Dec 4, 2009·American Journal of Physiology. Renal Physiology·Toru SakairiJeffrey B Kopp
Jan 4, 2005·Nephron. Experimental Nephrology·Arndt T PetermannStuart J Shankland
Apr 26, 2006·Nephron. Experimental Nephrology·John M BasgenJens R Nyengaard
Jun 3, 2006·Nephron. Clinical Practice·James C M Chan, Howard Trachtman
Apr 9, 2008·Nephron. Experimental Nephrology·Shigetaka YoshidaToshiro Fujita
Jan 5, 2011·American Journal of Nephrology·Xiao Yan Bai, John M Basgen
Jun 17, 2011·American Journal of Nephrology·Susanne B NicholasSatyesh Sinha
May 25, 2011·American Journal of Nephrology·Katsuhiko AsanumaYasuhiko Tomino
Mar 30, 2012·American Journal of Nephrology·Qingxian ZhangHai-Yan Wang
Oct 26, 2012·Nephron. Experimental Nephrology·L WangR F Spurney
Mar 5, 2010·The Journal of Clinical Investigation·Björn HartlebenTobias B Huber
May 25, 2011·The Journal of Clinical Investigation·Ken InokiKun-Liang Guan
Jan 22, 2011·Journal of Translational Medicine·José M López-NovoaFrancisco J López Hernández
Dec 19, 2013·PloS One·Stefano Da SaccoLaura Perin
Apr 25, 2009·Journal of the American Society of Nephrology : JASN·Yuji SatoRoger C Wiggins
Sep 17, 2009·Internal Medicine·Masaaki MiyauchiDaisuke Suzuki
Mar 5, 2011·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Hiroshi Kajiyama
Jun 16, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Rin AsaoYasuhiko Tomino

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