Podophyllum hexandrum aqueous extract as a potential free radical scavenger.

Redox Report : Communications in Free Radical Research
Showkat Ahmad GanieMohammad Afzal Zargar

Abstract

The present study was undertaken to evaluate the effect of the aqueous extract of Podophyllum hexandrum against free radical-mediated damage and also explore its anticancer activity. The extract exhibited significant activity in scavenging 1, 1-diphenyl-2-picryl-hydrazyl radicals, (•)OH radical-mediated DNA damage, and lipid peroxide production in rat liver microsomes. The extract was also tested for its reducing abilities. The activity of liver marker enzymes and antioxidant defense enzymes in rat liver homogenate was assessed in control and carbon tetrachloride (CCl(4))-treated animals. It was observed that CCl(4)-induced changes viz., increases in the activities of aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase, a decrease in reduced glutathione as well as decreases in the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione-S-transferase. All these parameters showed reversal when pretreated with aqueous extract of P. hexandrum. Podophylotoxin and etoposide are the two known anticancer agents derived from P. hexandrum and interestingly the aqueous extract of P. hexandrum showed a typical DNA ladder formation in HL-60 cells confirming its...Continue Reading

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Citations

Apr 16, 2014·Oxidative Medicine and Cellular Longevity·Showkat Ahmad GanieMohammad Afzal Zargar
Jul 7, 2020·Journal of Food Science and Technology·Mukul KumarRavinder Kaushik

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