Podoplanin emerges as a functionally relevant oral cancer biomarker and therapeutic target

Oral Oncology
Edward P RetzbachGary S Goldberg

Abstract

Oral cancer has become one of the most aggressive types of cancer, killing 140,000 people worldwide every year. Current treatments for oral cancer include surgery and radiation therapies. These procedures can be very effective; however, they can also drastically decrease the quality of life for survivors. New chemotherapeutic treatments are needed to more effectively combat oral cancer. The transmembrane receptor podoplanin (PDPN) has emerged as a functionally relevant oral cancer biomarker and chemotherapeutic target. PDPN expression promotes tumor cell migration leading to oral cancer invasion and metastasis. Here, we describe the role of PDPN in oral squamous cell carcinoma progression, and how it may be exploited to prevent and treat oral cancer.

Citations

Sep 12, 2019·Journal of Applied Oral Science : Revista FOB·Sonali PradhanMonica Charlotte Solomon
Mar 18, 2020·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Yukinari KatoMika K Kaneko
Apr 3, 2018·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Shinji YamadaYukinari Kato
Oct 27, 2018·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Yukinari KatoMika K Kaneko
Jun 20, 2020·American Journal of Rhinology & Allergy·Huan WangDehui Wang
May 26, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Fernanda Weber MelloElena Riet Correa Rivero
Oct 18, 2019·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Masato SanoYukinari Kato
Nov 19, 2020·Journal of Cancer Research and Clinical Oncology·Kelly L HamiltonGary S Goldberg
May 28, 2021·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Tomohiro TanakaMika K Kaneko
Jun 25, 2021·Frontiers in Immunology·Joshua H BourneJulie Rayes
Sep 7, 2021·Genesis : the Journal of Genetics and Development·Masako Toda NakamuraYuji Mishina
Sep 14, 2021·Technology in Cancer Research & Treatment·Xiaohang WangJiaxin Zhang
Dec 24, 2021·Chinese Medical Journal·Zhi-Yun Liu, Chun-Guang Zhao

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