Podoplanin serum and urine concentration in transitional bladder cancer

Cancer Biomarkers : Section a of Disease Markers
Anna SankiewiczEwa Gorodkiewicz

Abstract

Podoplanin (PDP) is a mucin - a type of transmembrane protein expressed in numerous tissues during ontogeny and in adult animals, including the brain, heart, kidney, osteoblasts and lymphoid organs. The aim of this study was to determine podoplanin concentration in the blood serum and urine of patients with bladder cancer. Quantifying podoplanin concentration and its correlation with various clinicopathological parameters may be useful for more accurate predictions and identifying high-risk patients. The present study included 82 patients with bladder cancer confirmed by transurethral resection or cystectomy and 27 healthy volunteers. The Surface Plasmon Resonance Imaging biosensor was applied for the detection of podoplanin in the serum and urine samples. Significant differences in serum and urine podoplanin concentration levels were observed between bladder cancer patients. The statistically significant higher values of PDP were detected in serum of patients with invasive, more aggressive, larger, multifocal tumors. The association between podoplanin concentration and clinicopathological features indicates that it might be useful while making therapeutic decisions.

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Citations

Oct 22, 2016·Analytical Biochemistry·A SankiewiczE Gorodkiewicz
Mar 31, 2017·Cellular and Molecular Bioengineering·Anna SankiewiczEwa Gorodkiewicz
Mar 14, 2018·Journal of Burn Care & Research : Official Publication of the American Burn Association·Ewa MatuszczakAdam Hermanowicz
Dec 19, 2018·Biosensors·Ewa Gorodkiewicz, Zenon Lukaszewski
Feb 10, 2019·International Journal of Molecular Sciences·Miguel QuintanillaEster Martín-Villar
Apr 3, 2020·Molecular Cancer Research : MCR·Axel JohnChristian Gorzelanny
Dec 12, 2020·Journal of Pharmaceutical and Biomedical Analysis·Pawel FalkowskiEwa Gorodkiewicz
Jan 14, 2021·Analytical Methods : Advancing Methods and Applications·Anna SankiewiczEwa Gorodkiewicz
Jul 24, 2021·Journal of Proteomics·Rubén López-CortésCristina Núñez
Jul 20, 2017·ACS Sensors·Jean-Francois Masson

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