POINT: a database for the prediction of protein-protein interactions based on the orthologous interactome

Bioinformatics
Tao-Wei HuangChi-Ying F Huang

Abstract

One possible path towards understanding the biological function of a target protein is through the discovery of how it interfaces within protein-protein interaction networks. The goal of this study was to create a virtual protein-protein interaction model using the concepts of orthologous conservation (or interologs) to elucidate the interacting networks of a particular target protein. POINT (the prediction of interactome database) is a functional database for the prediction of the human protein-protein interactome based on available orthologous interactome datasets. POINT integrates several publicly accessible databases, with emphasis placed on the extraction of a large quantity of mouse, fruit fly, worm and yeast protein-protein interactions datasets from the Database of Interacting Proteins (DIP), followed by conversion of them into a predicted human interactome. In addition, protein-protein interactions require both temporal synchronicity and precise spatial proximity. POINT therefore also incorporates correlated mRNA expression clusters obtained from cell cycle microarray databases and subcellular localization from Gene Ontology to further pinpoint the likelihood of biological relevance of each predicted interacting sets o...Continue Reading

Citations

Oct 13, 2006·Journal of Molecular Evolution·Jaroslav KubrychtPetr Jezek
Apr 1, 2006·Planta·Joachim F Uhrig
Apr 23, 2008·Amino Acids·Xing-Ming ZhaoKazuyuki Aihara
Apr 24, 2008·Amino Acids·Yonge Feng, Liaofu Luo
Aug 23, 2008·Amino Acids·Xiaoqi ZhengJun Wang
Dec 15, 2010·Interdisciplinary Sciences, Computational Life Sciences·Nagasuma ChandraKalidas Yeturu
Aug 6, 2005·Nature Biotechnology·Daniel R RhodesArul M Chinnaiyan
Jan 20, 2005·Bioinformatics·Kevin R Brown, Igor Jurisica
Apr 26, 2007·Bioinformatics·Andreas SchlickerMario Albrecht
May 30, 2008·Bioinformatics·Magali MichautHenning Hermjakob
Aug 12, 2008·Bioinformatics·Chia-Ying YangChi-Ying F Huang
May 8, 2009·Bioinformatics·Hagen BlankenburgMario Albrecht
Nov 8, 2008·Nucleic Acids Research·Mark D McDowallGeoffrey J Barton
Jun 9, 2009·Nucleic Acids Research·Hagen BlankenburgMario Albrecht
Nov 11, 2009·Nucleic Acids Research·Petras J KundrotasIlya A Vakser
Aug 7, 2007·Annual Review of Genetics·Kara Dolinski, David Botstein
Apr 22, 2009·BMC Bioinformatics·Sheng-An LeeChi-Ying F Huang
May 19, 2009·BMC Bioinformatics·Nazar ZakiPiers Campbell
Feb 15, 2005·BMC Bioinformatics·Harold J DrabkinJudith A Blake
May 12, 2007·BMC Bioinformatics·Tao-Wei HuangCheng-Yan Kao
Sep 20, 2008·BMC Genomics·Paul M K GordonKarl Riabowol
Aug 6, 2010·Source Code for Biology and Medicine·Chandra Sekhar Pedamallu, Janos Posfai
Apr 1, 2010·BMC Systems Biology·Amy M WilesAlexander J R Bishop
Dec 17, 2005·Genome Biology·Danielle KemmerB F Francis Ouellette
Oct 3, 2012·PLoS Computational Biology·Anna C F LewisCharlotte M Deane
Nov 26, 2009·Briefings in Bioinformatics·Artem LysenkoChristopher John Rawlings
Feb 10, 2007·Expert Review of Proteomics·Jimmy Lin, Jiang Qian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.