Point-of-Care Fibrinogen Testing in Pregnancy

Anesthesia and Analgesia
Daniel KatzYaakov Beilin

Abstract

Agreement between estimated fibrinogen concentration via thromboelastography and traditional assays is not established in the parturient. We therefore recruited 56 parturients and performed Clauss and functional fibrinogen level (FLEV) tests. Mean difference of measurements was 36.8 mg/dL (95% CI, 21.8-51.9) with a standard deviation of 52.8 mg/dL. Calculated limits of agreement were 140.2 mg/dL (95% CI, 166.3-114.6) and -66.6 mg/dL (95% CI, -40.8 to -92.5), within the maximum allowable difference of 165 mg/dL. We therefore conclude that while most measurements fell within the limits of agreement, more work is needed to clearly define the role of this test in the obstetric population.

References

Feb 9, 2007·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vance G NielsenWilliam L Holman
May 23, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·C HuissoudR-C Rudigoz
Jun 5, 2012·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Ivo FlugerVladimir Lonsky
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May 2, 2014·Anesthesia and Analgesia·Anna AgrenGustaf Edgren
Oct 21, 2014·Anesthesia and Analgesia·Anne-Sophie Ducloy-BouthorsEvelyn Lockhart
Sep 5, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lesley De PietriErica Villa
Aug 25, 2016·Anesthesia and Analgesia·Ruth ShaylorAlexander J Butwick

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Citations

May 2, 2020·Journal of Thrombosis and Haemostasis : JTH·Ariunzaya AmgalanHoma K Ahmadzia

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