Point-of-Care Identification of Bacteria Using Protein-Encapsulated Gold Nanoclusters

Advanced Healthcare Materials
Haiwei JiXiaogang Qu

Abstract

The rapid, simple, and reliable identification of the most prevalent pathogens is essential for clinical diagnostics, biology, and food safety. Herein, four protein-encapsulated gold nanoclusters (protein-AuNCs) are designed and prepared as a sensor array for rapid identification of bacteria. The discrimination of six kinds of bacteria, including two kinds of drug-resistant bacteria, is successfully realized by the as-fabricated sensor array. The strategy presented here shows the advantages of easy synthesis and convenient to use. Furthermore, 100% classification accuracy is achieved by the sensor array consisting of two protein-AuNCs probes, demonstrating the design with sufficient diagnostic capacity. Taken together, the developed sensor array holds great promise for facile diagnosis of bacterial infection in resource-limited settings.

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Citations

Nov 21, 2019·Nanoscale·Dan LiVincent Rotello
Apr 9, 2020·Frontiers in Chemistry·Mingxiu TangHui Jiang
Jul 21, 2021·Chemical Reviews·W Russ AlgarHyungki Kim
Apr 10, 2019·ACS Applied Materials & Interfaces·Xiaojuan LiuFeng Li
Sep 29, 2018·Analytical Chemistry·Hao QiuXiaogang Qu

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