Point-of-Use Rapid Detection of SARS-CoV-2: Nanotechnology-Enabled Solutions for the COVID-19 Pandemic

International Journal of Molecular Sciences
Navid RabieeRajender S Varma

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the COVID-19 pandemic that has been spreading around the world since December 2019. More than 10 million affected cases and more than half a million deaths have been reported so far, while no vaccine is yet available as a treatment. Considering the global healthcare urgency, several techniques, including whole genome sequencing and computed tomography imaging have been employed for diagnosing infected people. Considerable efforts are also directed at detecting and preventing different modes of community transmission. Among them is the rapid detection of virus presence on different surfaces with which people may come in contact. Detection based on non-contact optical techniques is very helpful in managing the spread of the virus, and to aid in the disinfection of surfaces. Nanomaterial-based methods are proven suitable for rapid detection. Given the immense need for science led innovative solutions, this manuscript critically reviews recent literature to specifically illustrate nano-engineered effective and rapid solutions. In addition, all the different techniques are critically analyzed, compared, and contrasted to identify the most promising methods. Moreover...Continue Reading

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Citations

Nov 10, 2020·Expert Review of Anti-infective Therapy·Mahendra RaiAvinash P Ingle
Jan 28, 2021·Nanomedicine·Navid RabieeThomas J Webster
Feb 4, 2021·Trends in Analytical Chemistry : TRAC·Annasamy GowriB S Suresh Anand
Jan 6, 2021·MRS Communications·Tanveer A TabishMohan Edirisinghe
Jan 19, 2021·3 Biotech·Naun Lobo-GaloEduardo Ruiz-Bustos
Feb 28, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Fernanda PilaquingaMaría de Las Nieves Piña
Feb 23, 2021·Emergent Materials·Farzan Vahedifard, Krishnan Chakravarthy
Mar 16, 2021·ACS Omega·Tamsyn StanboroughDeborah L Crittenden
May 1, 2021·Infectious Disease Reports·Anu MaharjanKomal Raj Rijal
May 1, 2021·International Journal of Environmental Research and Public Health·Hamid MukhtarRoobaea Alroobaea
May 18, 2021·Journal of Inorganic and Organometallic Polymers and Materials·Pierre D Harvey, Jessica Plé
Jun 28, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Akbar HasanzadehMichael R Hamblin
Aug 12, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mina ZareSeeram Ramakrishna
Aug 22, 2021·International Journal of Biological Macromolecules·Mehrnaz EbrahimiAli Akbar Moosavi-Movahedi

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Methods Mentioned

BETA
transmission electron microscopy
PCR
nucleic acids amplification assay
electrophoresis
enzyme-linked immunosorbent
biosensors
Fluorescence
biosensor
surface plasmon resonance
light scattering

Software Mentioned

RT
SHERLOCK
LAMP

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