Poisoning by Indigofera lespedezioides in horses

Toxicon : Official Journal of the International Society on Toxinology
Everton F LimaGabriela Riet-Correa

Abstract

Poisoning by Indigofera lespedezioides is reported in horses in the state of Roraima, northern Brazil. The main clinical signs are anorexia, sleepiness, unsteady gait, severe ataxia, weakness, stumbling, and progressive weight loss. To induce the disease experimentally, a 7-year-old horse was introduced in a small paddock invaded by the plant. The first nervous signs were observed 44 days from the start of grazing. The animal was euthanized on day 59. No significant gross lesions were observed upon necropsies of the experimental horse as well as one spontaneously affected horse. Upon histologic examination neuronal lipofuscinosis was observed in the brain, cerebellum, and spinal cord. Wallerian-type degeneration was observed on some mesencephalic tracts. Neuronal and axonal degeneration and lipofuscinosis were observed on electron microscopy examination. Indospicine was detected in four samples of I. lespedezioides with concentrations ranging from 63 to 1178 μg/g whereas nitro toxins could be detected in only one of the samples at a concentration of 2.5 mg/g. In conclusion, poisoning by I. lespedezioides is very similar to those poisonings by Indigofera linnaei and Indigofera hendecaphylla. Based on the preponderance of indospi...Continue Reading

References

Jul 1, 1971·Australian Veterinary Journal·P T HooperG W Smith
Jul 1, 1982·Veterinary Pathology·W J HartleyP Daynes
Jul 21, 2005·New Zealand Veterinary Journal·N G GregoryD R Harding
Feb 18, 2011·Australian Veterinary Journal·L M FitzGeraldA J O'Hara

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