Polar steroid derivatives from the Vietnamese starfish Astropecten polyacanthus

Natural Product Research
Le Thi VienChau Van Minh

Abstract

Five polar steroid derivatives, including one new glycosylated polyhydroxysteroid namely polyacanthoside A (1), were isolated from the water-soluble materials from the MeOH extract of the Vietnamese starfish Astropecten polyacanthus using various chromatographic separations. The structure elucidation was confirmed by spectroscopic experiments such as HR-ESI-MS, 1D and 2D NMR. Among the isolated compounds, (20R,24S)-3β,6α,8,15β,24-pentahydroxy-5α-cholestane (3) showed significant cytotoxic effect against five human cancer cell lines as HepG2, KB, LNCaP, MCF7 and SK-Mel2 with the IC50 values from 18.03 ± 2.63 to 21.59 ± 3.23 μM.

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Citations

Jan 8, 2020·Chemistry & Biodiversity·Jin-Mei XiaXian-Wen Yang
Feb 7, 2020·Natural Product Reports·Anthony R CarrollMichèle R Prinsep

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Datasets Mentioned

BETA
AP052016

Methods Mentioned

BETA
NMR

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