Polarisation of Tumor-Associated Macrophages toward M2 Phenotype Correlates with Poor Response to Chemoradiation and Reduced Survival in Patients with Locally Advanced Cervical Cancer

PloS One
Marco PetrilloGiovanni Scambia

Abstract

We investigate the prognostic role of pre-treatment ratio between Type 1 (M1) and Type 2 (M2) tumor-associated macrophages (TAMs) in locally advanced cervical cancer (LACC) patients treated with chemoradiation (CT/RT). 84 consecutive LACC patients treated with cisplatin-based CT/RT for a total dose of 50.0 Gy, followed by radical surgery were analysed. Double-staining immunohistochemistry of CD163/p-STAT, CD68/pSTAT1, CD163/c-MAF, and CD68/c-MAF was performed on tumor samples taken at the time of diagnosis. TAMs with CD163+pSTAT1+, or CD68+pSTAT1+ were defined M1; CD163+c-MAF+ or CD68+c-MAF+ defined the M2 phenotype. The number of M1 and M2 cells was counted at low magnification by evaluating for each case the same tumour area. The ratio between M1 and M2 (M1/M2) was finally calculated. At diagnosis, we observed a direct correlation between the number of circulating monocytes and of TAMs (p-value = 0.001). Patients with high M1/M2 experienced more frequently complete pathologic response (no residual tumor) to CT/RT, compared to cases with low M1/M2 (55.0% Vs 29.5%; p-value = 0.029). At multivariate analysis M1/M2 (OR = 2.067; p-value = 0.037) emerged as independent predictor of pathologic response to CT/RT. Women with high M1/M...Continue Reading

References

Mar 24, 1999·Journal of the National Cancer Institute·C McNeil
Apr 15, 1999·The New England Journal of Medicine·P G RoseS Insalaco
Apr 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W A PetersD S Alberts
Jun 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C D MillsA M Hill
Sep 6, 2002·The American Journal of Pathology·Sebastian F SchoppmannDontscho Kerjaschki
Nov 7, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·UNKNOWN Neoadjuvant Chemotherapy for Locally Advanced Cervical Cancer Meta-analysis Collaboration
Sep 10, 2005·Gynecologic Oncology·Distefano MariagraziaScambia Giovanni
Sep 22, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·J M MartínE Jordá
Oct 16, 2007·Gynecologic Oncology·Jasenka MazibradaMarisa Gariglio
Mar 5, 2008·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Gian Franco ZannoniArnaldo Carbone
May 10, 2008·Seminars in Cancer Biology·Antonio SicaAlberto Mantovani
Jan 5, 2013·Biochimica Et Biophysica Acta·Heon-Woo LeeYoung-Guen Kwon
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jun 7, 2013·International Journal of Cancer. Journal International Du Cancer·P J de Vos van SteenwijkE S Jordanova
Jul 31, 2013·Oncoimmunology·Paola AllavenaAlberto Mantovani
Sep 5, 2013·JAMA : the Journal of the American Medical Association
Nov 22, 2013·PloS One·Mário Henrique M BarrosGerald Niedobitek
Feb 21, 2014·The New England Journal of Medicine·Krishnansu S TewariBradley J Monk

❮ Previous
Next ❯

Citations

Feb 25, 2017·Gynecologic Oncology·Kari L RingAmir A Jazaeri
Jul 10, 2019·International Journal of Molecular Sciences·Qun WangHelene Heidegger
Aug 16, 2016·Cell and Tissue Research·Zareen Khan, John F Marshall
Jul 7, 2018·Journal of Experimental & Clinical Cancer Research : CR·Marconi Rego BarrosAldo Venuti
Jul 7, 2019·International Journal of Molecular Sciences·Isao Otsuka
May 22, 2018·Magnetic Resonance Insights·Runze YangJeff F Dunn
Jul 10, 2020·Neuro-oncology Advances·Dustin T ProctorGarnette R Sutherland
Oct 13, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Li LiXin-Yan Xu
May 13, 2017·International Journal of Oncology·Marlies SchrevelEkaterina S Jordanova
Jan 27, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Grzegorz SzewczykDariusz Szukiewicz
Feb 23, 2020·BioMed Research International·Yi LiuXia Zhao
Jul 23, 2016·Pathology International·Motohiro Takeya, Yoshihiro Komohara
Dec 7, 2020·Critical Reviews in Oncology/hematology·Divya AdigaShama Prasada Kabekkodu
Dec 18, 2020·Frontiers in Immunology·Alisha ChettyWilliam Horsnell
Apr 4, 2021·International Journal of Molecular Sciences·Galina F MedvedevaMarina S Dukhinova
Mar 3, 2021·JCI Insight·Samuel T PellomCaroline Jochems
Apr 14, 2021·Journal of Experimental & Clinical Cancer Research : CR·Domenico MattoscioAntonio Recchiuti
Aug 30, 2019·International Immunopharmacology·Keywan MortezaeeBagher Farhood

❮ Previous
Next ❯

Methods Mentioned

BETA
hysterectomy
biopsies

Software Mentioned

Statistical Package for Social Sciences
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.