Polarization-sensitive optical coherence tomography reveals gray matter and white matter atrophy in SCA1 mouse models

Neurobiology of Disease
Chao J LiuTaner Akkin

Abstract

Spinocerebellar ataxia type 1 (SCA1) is a fatal inherited neurodegenerative disease. In this study, we demonstrate the label-free optical imaging methodology that can detect, with a high degree of sensitivity, discrete areas of degeneration in the cerebellum of the SCA1 mouse models. We used ATXN1[82Q] and ATXN1[30Q]-D776 mice in which the transgene is directed only to Purkinje cells. Molecular layer, granular layer, and white matter regions are analyzed using the intrinsic contrasts provided by polarization-sensitive optical coherence tomography. Cerebellar atrophy in SCA1 mice occurred both in gray matter and white matter. While gray matter atrophy is obvious, indications of white matter atrophy including different birefringence characteristics, and shortened and contorted branches are observed. Imaging results clearly show the loss or atrophy of myelinated axons in ATXN1[82Q] mice. The method provides unbiased contrasts that can facilitate the understanding of the pathological progression in neurodegenerative diseases and other neural disorders.

References

Feb 1, 1995·Seminars in Cell Biology·H Y Zoghbi, H T Orr
Oct 8, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tao ZuHarry T Orr
Mar 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gülin OzH Brent Clark
Feb 9, 2012·Neuropathology and Applied Neurobiology·U RübT Deller
Jun 12, 2012·Acta Neuropathologica·Kay SeidelUdo Rüb
Feb 14, 2015·The American Statistician·Peter H Westfall
Jun 26, 2015·PloS One·Othman I AlomairNyoman D Kurniawan
Oct 12, 2016·Neurophotonics·Chao J LiuTaner Akkin
Dec 27, 2016·Biomedical Optics Express·Sreyankar NandyQuing Zhu
Apr 14, 2017·Nature·Daniel R ScolesStefan M Pulst

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Related Papers

Ryōikibetsu shōkōgun shirīzu
T UchiyamaT Hattori
Journal of Cardiovascular Electrophysiology
Michael JenkinsIgor R Efimov
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Blake A EbnerHarry T Orr
© 2022 Meta ULC. All rights reserved