Polarized expression of the receptor protein tyrosine kinase Cek5 in the developing avian visual system

Developmental Biology
J A Holash, E B Pasquale

Abstract

Receptor protein tyrosine kinases of the Eph subfamily have been proposed to play roles in pattern formation based on their distribution during embryonic development. Cek5 (chicken embryo kinase 5) and Cek8 (chicken embryo kinase 8) are Eph-related kinases highly expressed in the chicken embryonic retina. To assess their potential roles in the development of the visual pathway, we examined their distribution by immunoperoxidase labeling. Cek8 is expressed throughout the pathway of the retinal ganglion cell axons, including the nerve fiber layer of the retina, optic nerve, optic chiasm, and stratum opticum of the tectum. Cek5 immunoreactivity is highly concentrated in only a portion of the optic nerve and optic chiasm, and in retinal cultures, Cek5 is detected in neurons. This prompted us to examine the regional distribution of Cek5 in the developing retina and led to the observation that Cek5 is most concentrated in the ventral aspect. RT-PCR established that the differential regulation of Cek5 expression in different portions of the retina occurs at the transcriptional level. Immunoblotting analysis revealed that this unusual expression pattern is distinctive for Cek5, as three other members of the Eph subfamily, Cek4, Cek8, a...Continue Reading

Citations

Oct 19, 1999·The Journal of Comparative Neurology·S L CochranE W Rubel
Mar 15, 1997·Journal of Neuroscience Research·A H ZischE B Pasquale
Jul 20, 2006·Experimental Brain Research·Sherralee S LukehurstJennifer Rodger
May 12, 1998·Pharmacology & Therapeutics·R Zhou
Feb 15, 2001·Brain Research. Developmental Brain Research·J A St John, B Key
Sep 1, 1997·Trends in Genetics : TIG·D Orioli, R Klein
Jun 1, 2000·Progress in Neurobiology·C A Stuermer, M Bastmeyer
Oct 23, 1997·Current Opinion in Cell Biology·E B Pasquale
Aug 1, 1996·Current Opinion in Genetics & Development·B K MüllerU Drescher
Feb 21, 2003·Current Opinion in Neurobiology·Todd McLaughlinDennis D M O'Leary
Feb 1, 1996·Current Opinion in Neurobiology·G C Friedman, D D O'Leary
Feb 1, 1997·Current Opinion in Neurobiology·U DrescherB K Müller
Mar 11, 1999·Current Opinion in Neurobiology·D D O'Leary, D G Wilkinson
Sep 29, 1998·The European Journal of Neuroscience·T CiossekU Drescher
Aug 30, 2008·The Journal of Biological Chemistry·Roberta NoberiniElena B Pasquale
Mar 17, 1997·The EMBO Journal·B MonschauU Drescher
Oct 11, 2005·Annual Review of Cell and Developmental Biology·Greg Lemke, Michaël Reber
Apr 8, 1998·Annual Review of Neuroscience·J G Flanagan, P Vanderhaeghen
Dec 31, 2010·BMC Neuroscience·Dmitry Tsigankov, Alexei A Koulakov
Sep 2, 2004·BMC Neuroscience·Alexei A Koulakov, Dmitry N Tsigankov
Jan 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·T L JonesI O Daar
Apr 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Elva DíazJohn Ngai
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·P P GaoR Zhou
Jul 4, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Roberta NoberiniElena B Pasquale
Apr 16, 2008·Journal of Neurochemistry·David BouvierGuy Doucet
Jul 28, 2011·Chemical Biology & Drug Design·Roberta NoberiniElena B Pasquale
Apr 1, 2006·Molecular and Cellular Neurosciences·Timothy J PetrosCarol A Mason
Aug 23, 2005·Brain Research. Brain Research Reviews·Albert Martínez, Eduardo Soriano
Dec 16, 2005·Network : Computation in Neural Systems·Geoffrey J Goodhill, Jun Xu
Feb 13, 2001·Developmental Biology·P MenzelE B Pasquale
Nov 22, 2000·Molecular and Cellular Neurosciences·J WalkenhorstU Drescher
Oct 30, 2007·Neuron·Liqun Luo, John G Flanagan
Apr 5, 2001·Mechanisms of Development·C Naruse-NakajimaY Iwakura
Dec 1, 1996·Neuron·M A Nieto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.