Polarized localization of epithelial CXCL11 in chronic obstructive pulmonary disease and mechanisms of T cell egression.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Joanna C PorterAlan Hall

Abstract

The exit of lymphocytes from the interstitium of the lung, across the bronchial epithelium and into the airway lumen, is known as egression, or luminal clearance. Egression is important for immune surveillance and the resolution of inflammation, but the mechanisms involved are unknown. We show that egression of human T cells across the bronchial epithelium is a multistep process, driven in part by a polarized transepithelial gradient of CXCL11 that is up-regulated in patients with chronic obstructive airways disease. Previous studies have shown that T cells can migrate across a disrupted bronchial epithelium, but we provide evidence that egression does not require epithelial injury, and can take place across an intact epithelial barrier. After negotiating the extracellular matrix, the T cell adheres to the basal surface of the bronchial epithelial cell using alpha(4) and leukocyte function associated-1 integrins before crossing the epithelium in an leukocyte function associated-1-dependent way. We demonstrate an egression-dependent decrease in transepithelial resistance across the epithelium without gross alteration in tight-junction proteins. The process of egression has been relatively overlooked when considering the control ...Continue Reading

References

Jan 1, 1992·The Journal of Cell Biology·I DransfieldN Hogg
Feb 1, 1995·American Journal of Respiratory and Critical Care Medicine·R Pabst, R M Binns
Dec 21, 2000·The Journal of Cell Biology·N SignoretM Marsh
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·R J HoganD L Woodland
May 5, 2001·Expert Opinion on Pharmacotherapy·F Sánchez-Madrid, R González-Amaro
Jun 8, 2001·The Journal of Clinical Investigation·P Panina-BordignonF Sinigaglia
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A M ColeR M Strieter
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S K ShawF W Luscinskas
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K Soejima, B J Rollins
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·L UllerJ S Erjefält
Jan 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jaap D van BuulPeter L Hordijk
Feb 6, 2002·The Journal of Experimental Medicine·Nicola L HarrisGraham Le Gros
Mar 29, 2002·Nature Immunology·Dean Sheppard
May 23, 2002·American Journal of Respiratory and Critical Care Medicine·Marina SaettaLeonardo M Fabbri
Jun 11, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karkada MohanThomas B Issekutz
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heather A EdensCharles A Parkos
Sep 11, 2002·Molecular Biology of the Cell·Carolyn B CoyneLarry G Johnson
Sep 18, 2002·Immunological Reviews·Nancy HoggPaula Stanley
Apr 18, 2003·American Journal of Physiology. Cell Physiology·Sandra van WeteringPeter L Hordijk
Oct 22, 2003·The Journal of Experimental Medicine·Ian R HumphreysTracy Hussell
Mar 17, 2004·Nature Immunology·Alan R SchenkelWilliam A Muller
Apr 3, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·David B CorryFarrah Kheradmand
Aug 18, 2004·Trends in Molecular Medicine·Tracy HussellAndrew E Williams
Oct 22, 2004·The Biochemical Journal·Jaime Millán, Anne J Ridley
Jun 29, 2005·The Journal of Cell Biology·Andrew SmithNancy Hogg
Aug 23, 2005·Proceedings of the American Thoracic Society·David L Woodland, Iain Scott
Aug 24, 2005·Nature Immunology·Gudrun F DebesEugene C Butcher
Nov 23, 2005·The Journal of Experimental Medicine·Godelieve J de BreeRené A W van Lier
Dec 13, 2005·American Journal of Respiratory and Critical Care Medicine·Valerie Guyot-RevolAjit Lalvani
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kenneth H ElyDavid L Woodland
Jan 13, 2006·PLoS Medicine·Joseph P Mizgerd
Feb 3, 2006·The European Respiratory Journal·A D LopezS Buist
Feb 10, 2006·American Journal of Physiology. Cell Physiology·Syed ShahabuddinSteven G Kelsen
Jul 11, 2006·Immunological Reviews·Hirokazu HikonoDavid L Woodland
Aug 31, 2006·The Journal of Experimental Medicine·Jennifer M BurnsThomas J Schall
Nov 30, 2006·PLoS Medicine·Colin D Mathers, Dejan Loncar

❮ Previous
Next ❯

Citations

Oct 10, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Joanna C Porter, Alan Hall
Jun 15, 2010·Respiratory Research·Carl G Persson, Lena Uller
May 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Justin A GreenJon S Friedland
Jun 9, 2019·International Journal of Molecular Sciences·Pauline HenrotIsabelle Dupin
Jan 3, 2013·Immunological Reviews·Mike HasenbergMatthias Gunzer
Nov 8, 2011·British Journal of Pharmacology·Carl Persson, Lena Uller
Oct 4, 2013·Brain : a Journal of Neurology·Gilad KunisMichal Schwartz
Nov 4, 2015·Scientific Reports·Colin A BretzJohn S Penn
Feb 20, 2009·Current Opinion in Pulmonary Medicine

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Joanna C Porter, Alan Hall
The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
C CorauxD Gaillard
American Journal of Respiratory Cell and Molecular Biology
Jonas S ErjefältCarl G A Persson
© 2021 Meta ULC. All rights reserved