Polarographic determination of some penicillins through nitrosation

Journal of Pharmaceutical and Biomedical Analysis
F BelalM Eid

Abstract

Direct current and differential pulse polarography DPP were used for the determination of three penicillins, namely, ampicillin, benzylpenicillin and carbenicillin, in pure form and in their dosage forms. The method is based upon treatment of penicillins with nitrous acid followed by polarographic measurement of the produced derivatives polarographically. The nitroso derivatives formed exhibited reduction waves over the whole pH range in Britton-Robinson buffers. The waves were characterized as being diffusion-controlled and free from adsorption phenomena. The current-concentration plots were rectilinear over the concentration range 8-200 and 2-160 micrograms ml-1 for DCt and DPP, respectively, for all the studied compounds. The proposed method was further applied to determine penicillins in pharmaceutical preparations, and the results obtained were in good agreement with those given by the companies.

References

Aug 1, 1967·Analytica Chimica Acta·P J Elving
Dec 1, 1969·Journal of Pharmaceutical Sciences·J P Hou, J W Poole
Aug 1, 1995·Journal of Pharmaceutical and Biomedical Analysis·F A AlyM I Walash

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Citations

Nov 30, 2000·Journal of Pharmaceutical and Biomedical Analysis·F BelalA A Al-Majed
Sep 3, 2013·Chemical & Pharmaceutical Bulletin·Ivana Rašić MišićEmilija Pecev-Marinković
Sep 15, 2006·Journal of Separation Science·Victoria F SamanidouIoannis N Papadoyannis
Sep 1, 2005·Luminescence : the Journal of Biological and Chemical Luminescence·Wei CaoQing-Fei Gao
Jun 29, 1999·Analytical Chemistry·R K Gilpin, L A Pachla

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