PMID: 7336122Oct 1, 1981Paper

Polarographic pO2 sensors with heparinized membranes for in vitro and continuous in vivo registration

Scandinavian Journal of Clinical and Laboratory Investigation
E NilssonP Olsson

Abstract

The membranes of the pO2 sensor in a conventional blood gas analyser and a commercially available catheter pO2 electrode were coated with a glutardialdehyde stabilized heparin layer. It was analysed whether or not the "non-thrombogenic" heparin surface could improve the accuracy of in vitro pO2 registration and continuous in vivo paO2 monitoring. The in vivo experiments were performed on anaesthetized and non-anticoagulated dogs. Two identical blood gas analysers were used, one furnished with a heparin coated pO2 membrane and the other with a standard pO2 membrane. In vitro pO2 determinations exhibited--when simultaneously analysing the same blood sample--identical mean values. For repeated pO2 determinations, however, the standard deviation was significantly lower on the analyser furnished with a heparinized membrane. The non-heparinized catheter pO2 electrode showed a marked deterioration in accuracy with time as compared with blood-gas analysis on reference blood samples. Falsely low paO2 values were presented. The heparinized catheter electrode monitored values in full agreement with those of the conventional blood gas analyser using standard membranes. It is concluded that the heparin surface on the oxygen diffusible membr...Continue Reading

References

Sep 1, 1978·American Journal of Clinical Pathology·P Blume
Jan 1, 1977·Scandinavian Journal of Plastic and Reconstructive Surgery·R Naas, L Traaholt
May 1, 1973·Scandinavian Journal of Clinical and Laboratory Investigation·A HuchG Rooth
May 1, 1965·Journal of Applied Physiology·C Lenfant, C Aucutt
Jan 1, 1961·Scandinavian Journal of Clinical and Laboratory Investigation·E ASMUSSEN, M NIELSEN

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Citations

Apr 1, 1993·Annals of Medicine·A FaúndesJ Díaz
Jan 1, 1983·Annals of the New York Academy of Sciences·P OlssonJ Swedenborg
Jan 1, 1987·Annals of the New York Academy of Sciences·R LarssonP Olsson
Feb 1, 1984·Clinical Physiology·E Nilsson, C Arnander
Jun 1, 1982·Scandinavian Journal of Clinical and Laboratory Investigation·E Nilsson, G Edwall
Jul 1, 1986·Journal of Clinical Monitoring·J W Severinghaus, P B Astrup
Jan 1, 1989·The American Journal of Physiology·S NielsenE I Christensen

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