Policaptil Gel Retard significantly reduces body mass index and hyperinsulinism and may decrease the risk of type 2 diabetes mellitus (T2DM) in obese children and adolescents with family history of obesity and T2DM

Italian Journal of Pediatrics
Stefano StagiMaurizio de Martino

Abstract

Treatments for childhood obesity are critically needed because of the risk of developing co-morbidities, although the interventions are frequently time-consuming, frustrating, difficult, and expensive. We conducted a longitudinal, randomised, clinical study, based on a per protocol analysis, on 133 obese children and adolescents (n = 69 males and 64 females; median age, 11.3 years) with family history of obesity and type 2 diabetes mellitus (T2DM). The patients were divided into three arms: Arm A (n = 53 patients), Arm B (n = 45 patients), and Arm C (n = 35 patients) patients were treated with a low-glycaemic-index (LGI) diet and Policaptil Gel Retard, only a LGI diet, or only an energy-restricted diet (ERD), respectively. The homeostasis model assessment of insulin resistance (HOMA-IR) and the Matsuda, insulinogenic and disposition indexes were calculated at T0 and after 1 year (T1). At T1, the BMI-SD scores were significantly reduced from 2.32 to 1.80 (p < 0.0001) in Arm A and from 2.23 to 1.99 (p < 0.05) in Arm B. Acanthosis nigricans was significantly reduced in Arm A (13.2% to 5.6%; p < 0.05), and glycosylated-haemoglobin levels were significantly reduced in Arms A (p < 0.005). The percentage of glucose-metabolism abnormal...Continue Reading

References

Nov 1, 1991·The American Journal of Clinical Nutrition·T M WoleverR G Josse
Oct 1, 1996·Diabetes Care·S M HaffnerH Miettinen
Mar 2, 1999·Pediatrics·D S LudwigS B Roberts
Mar 18, 2000·The Journal of Nutrition·D S Ludwig
Jul 10, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C MaffeisL Tatò
Jun 26, 2002·The American Journal of Clinical Nutrition·Kaye Foster-PowellJanette C Brand-Miller
Mar 18, 2003·The Journal of Pediatrics·Stephen B SondikeMarc S Jacobson
Feb 20, 2004·Public Health Nutrition·B A SwinburnW P T James
Mar 29, 2005·Diabetes Care·Ram WeissSonia Caprio
May 11, 2005·The American Journal of Clinical Nutrition·Cara B EbbelingDavid S Ludwig
Jun 24, 2006·European Journal of Endocrinology·Weibin ZhouMin Luo
Sep 8, 2006·Journal of Endocrinological Investigation·E CacciariA Cicognani
Sep 21, 2006·International Journal of Epidemiology·Lorna J GibsonIsabel dos Santos Silva
Dec 14, 2006·Reviews in Endocrine & Metabolic Disorders·Joyce M Lee
Sep 1, 2007·Medicine and Science in Sports and Exercise·Michelle M YoreCaroline A Macera
Dec 18, 2007·Pediatrics·Bonnie A SpearElsie M Taveras
Jan 29, 2010·Diabetes Care·UNKNOWN American Diabetes Association
Apr 7, 2010·Pediatrics·Stephanie BroylesGerald S Berenson
May 11, 2010·Lancet·Joan C HanSue Y S Kimm
Jun 3, 2010·European Journal of Endocrinology·Stefano StagiChiara Azzari
Jun 3, 2010·Hormone Research in Pædiatrics·S StagiMaurizio de Martino
May 11, 2012·Hormone Research in Pædiatrics·Amy M VedinMitchell E Geffner
Feb 19, 2013·BMC Medicine·Katherine HafekostStephen R Zubrick
Aug 21, 2013·World Journal of Diabetes·Andrea E ScaramuzzaGian Vincenzo Zuccotti
Nov 15, 2013·The New England Journal of Medicine·Matthew W Gillman, David S Ludwig
Dec 5, 2013·Diabetes Research and Clinical Practice·T TamayoW Rathmann
Dec 24, 2013·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·P Barat, C Lévy-Marchal
Jan 25, 2014·Hormones : International Journal of Endocrinology and Metabolism·Eleni P KotanidouAssimina Galli-Tsinopoulou
Feb 14, 2014·The American Journal of Clinical Nutrition·Rebecca C MollardJonathan M McGavock

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Citations

Aug 3, 2019·The American Journal of Clinical Nutrition·Mohammad Ishraq ZafarLu-Lu Chen
Nov 22, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M I ZafarL L Chen
Apr 28, 2021·Diabetes & Metabolic Syndrome·G GuarinoUNKNOWN Nefrocenter Research Study Group

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