Abstract
Insect wax is a famous biological resource for the role in economic production in China. Insect wax is a good source of policosanol, which may is a candidate supplement in foodstuff and pharmaceuticals that has important physiological activities. Therefore, this work aims to investigate a high-yield and rapid method for policosanol fabrication from insect wax. The conditions for policosanol fabrication were optimized as follows: an oil bath temperature of 112.7°C and reductant dosage of 0.97 g (used for the reduction of 10.00 g of insect wax). The yield of policosanol reached 83.20%, which was 4 times greater than that of existing methods, such as saponification. The total content of policosanol obtained under the optimal conditions reached 87%. In other words, a high yield of policosanol was obtained from insect wax (723.84 mg/g), that was 55 times higher than that generated from beeswax-brown via saponification. The concentrations of metal residues in policosanol were within the limits of the European Union regulations and EFSA stipulation. The LD50 values for oral doses of insect wax and policosanol were both > 5 g/kg. Policosanol was fabricated via solvent-free reduction from insect wax using LiAlH4 at a high yield. The fab...Continue Reading
References
Feb 1, 1992·International Journal of Immunopharmacology·I MoosbruggerJ Borg
May 1, 1991·Journal of Neuroscience Research·J Borg
Jun 4, 1990·Brain Research·J BorgC W Cotman
Feb 14, 1995·European Journal of Pharmacology·C DamgéG Ribes
Mar 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R L LipnickJ A Springer
Feb 1, 1993·Thrombosis Research·M L ArruzazabalaV Fraga
Jan 5, 2002·Archives of Toxicology·K OkazakiM Hirose
Feb 20, 2003·Nutrition·Johanna C TaylorG Brian Lockwood
Mar 3, 2004·Molecular Interventions·Efrain C Azmitia
Jun 15, 2007·Journal of Agricultural and Food Chemistry·Mei-Fei WangJie Li
Jun 3, 2008·Complementary Therapies in Medicine·F Francini-PesentiL Caregaro
Sep 9, 2009·Journal of Ethnopharmacology·Yuan QinYinlan Zhao
Jun 29, 2010·Acta Pharmacologica Sinica·Tao WangPing-ping Zuo
Nov 11, 2010·Journal of Agricultural and Food Chemistry·Aicha O CherifHabib Kallel
Aug 9, 2011·The Journal of International Medical Research·J H YangY S Zhu
Apr 27, 2012·PloS One·Pu YangYan-Fei Li
Dec 21, 2012·Journal of Biomedical Materials Research. Part a·Mohd Abul KalamAws Alshamsan
Sep 24, 2013·Food & Function·Francesca R LupiFrancesco Puoci
Mar 15, 2016·PloS One·Huan FangJibin Sun
Sep 10, 2016·PloS One·Wencheng HouYanping Luo
Mar 2, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhan-di WangXiao-Ming Chen