Pollen-food allergy syndrome is a common allergic comorbidity in adults with eosinophilic esophagitis

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
D LetnerJ Garber

Abstract

Eosinophilic esophagitis (EoE) is associated with atopic diseases including asthma, allergic rhinitis, and atopic dermatitis; however, limited data exist on the correlation between pollen-food allergy syndrome (PFAS) and EoE. We analyzed 346 adults with EoE treated at a single center between 2002 and 2016. Demographic and EoE-specific data including clinical features and measures of EoE disease severity and treatments were collected. The presence of other atopic diseases, family history, prevalence of peripheral eosinophilia and elevated IgE, and details of PFAS triggers were collected. Twenty six percent of the 346 subjects in our cohort had both EoE and PFAS (EoE-PFAS). Compared to subjects with EoE alone, subjects with EoE-PFAS had an increased frequency of allergic rhinitis (86.7% vs. 64.2%, P < 0.001) and family history of allergies (71.1% vs. 53.3%, P = 0.003), and comprised a higher proportion of EoE diagnoses made in the spring (Χ2 < 0.001). 43.3% of subjects with concurrent EoE and PFAS opted for treatment with elimination diet, and these measures failed to induce remission in 46.2% of cases. In most cases, elimination diet failed despite strict avoidance of PFAS trigger foods in addition to common EoE triggers includi...Continue Reading

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Citations

Mar 30, 2019·Current Opinion in Allergy and Clinical Immunology·Akiko Yagami, Motohiro Ebisawa
Dec 15, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Flávia Márcia de Castro E SilvaAna Paula Ferreira
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Nov 11, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Isabel SkypalaCarina Venter

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